Recent Advances in Adduct Science
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 640
Special Issue Editors
Interests: DNA adductomics; environmental carcinogenesis; mutational signatures; cancer prevention
Special Issue Information
Dear Colleagues,
Humans are exposed to an extremely large number of chemical substances in their daily lives. When these chemicals are taken into the body, they can be generally detoxified by drug-metabolizing enzymes, and usually excreted. Some of these chemicals however, can bind to proteins, nucleic acids, and other macromolecules in the body directly or after metabolic activation, to form adducts (addition + product). Some of these adducts have been widely used in epidemiological and mechanistic studies as biomarkers to elucidate the relationship between chemical substances and diseases.
Additionally, the biological effects of these adducts are known to be involved in the pathogenesis of various diseases, including cancer, through intracellular signal transduction, changes in gene expression, and the introduction of genomic mutations. Recently, with the development of innovative analytical techniques, not only an increasing number of protein- or nucleic acid-adducts have been discovered, but also their biological effects have been unveiled. Furthermore, these findings are expected to be applied to elucidate the precise mechanisms of disease development, to specify the etiology of diseases, to develop preventive strategies based on risk assessment, and eventually to lead to drug discovery.
The International Adductomics Consortium (IAC) was established 2023 with the aim of further developing the many possibilities of adduct science. The members of this consortium are researchers from various backgrounds who are interested in the biology of adducts, and the consortium aims to establish a platform to support this research by developing adduct databases and sharing resources and analytical methods with the scientific community. To mark the inauguration of the IAC, we would like to take this opportunity to organize a special issue, entitled Recent Advances in Adduct Science, as a forum to provide the latest information on adduct science research.
Dr. Yukari Totsuka
Dr. Haruhiko Sugimura
Guest Editors
Manuscript Submission Information
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Keywords
- adductomics
- protein- or nucleic acid-adducts
- biomarkers
- exposome
- genomic mutations
- disease etiology
- preventive strategies
- drug discovery
- risk assessment
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