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Biomolecules
Special Issues
Drug Delivery Nanosystems for Biomedical Applications
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Drug Delivery Nanosystems for Biomedical Applications

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2355

Special Issue Editors

Dr. Carla Vitorino

E-Mail Website
Guest Editor
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
Interests: nanotechnology; transdermal/topical systems; skin delivery; lipid nanoparticles; controlled release; brain drug delivery; cancer therapy; quality by design
Special Issues, Collections and Topics in MDPI journals
Dr. Carla Martins Lopes

E-Mail Website
Guest Editor
1. FP-BHS—Biomedical and Health Sciences Research Unit, FP-I3ID—Instituto de Investigação, Inovação e Desenvolvimento, Faculty of Health Science, Fernando Pessoa University, 4200-150 Porto, Portugal
2. UCIBIO—Applied Molecular Biosciences Unit, MedTech—Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, 050-313 Porto, Portugal
Interests: bioactive delivery systems; lipid-based nanosystems; hybrid nanosystems; controlled delivery; multifunctional nanosystems
Special Issues, Collections and Topics in MDPI journals
Dr. Marlene Lucio

E-Mail Website
Guest Editor
1. CF-UM-UP, Centro de Física das Universidades do Minho e Porto, Departamento de Física da Universidade do Minho, 4710-057 Braga, Portugal
2. CBMA, Centro de Biologia Molecular e Ambiental, Departamento de Biologia, Universidade do Minho, 4710-057 Braga, Portugal
Interests: nanocarriers; nanotherapeutics; membrane model systems; ADMET profiling; biophysical techniques
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanomedicine is a multidisciplinary area that has sparked the attention of many scientists worldwide. It offers numerous opportunities in the treatment and diagnosis of diseases, but several a priori barriers stand out, notably those related to biointeractions.

Several strategies have been developed to overcome such barriers. Proof of this is the diversity of nanocarrier systems and their multiple designs. They differ in nature, composition, structure, rearrangement, and surface chemistry. Ranging from stealth to bioconjugate modifications, these strategies facilitate the delivery of nanosystems to their target sites while preventing their accumulation in non-target tissues, ultimately ensuring more efficient therapeutic outcomes.

This Special Issue will cover the application of nanomedicine and drug delivery approaches for solving the emerging problems of classical medicine. An overview of the existing regulatory concepts of nanomaterials and nanomedicine is also welcome, along with strategies to ensure the safety, quality, and efficacy of the design methods for the development of nanomedicines. Basic research, in vitro and in vivo investigations, and pre-clinical studies are welcome.

Dr. Carla Vitorino
Dr. Carla M. Lopes
Dr. Marlene Lucio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanosystems
  • nanomedicine
  • controlled drug delivery
  • targeted delivery
  • theranostics

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

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Research

15 pages, 3677 KiB  
Article
Nanoparticle-Mediated Radiotherapy: Unraveling Dose Enhancement and Apoptotic Responses in Cancer and Normal Cell Lines
by Maria Anthi Kouri, Ellas Spyratou, Maria-Eleni Kalkou, Georgios Patatoukas, Evangelia Angelopoulou, Ioanna Tremi, Sophia Havaki, Vassilis G. Gorgoulis, Vassilis Kouloulias, Kalliopi Platoni and Efstathios P. Efstathopoulos
Biomolecules 2023, 13(12), 1720; https://doi.org/10.3390/biom13121720 - 29 Nov 2023
Cited by 1 | Viewed by 1775
Abstract
Cervical cancer remains a pressing global health concern, necessitating advanced therapeutic strategies. Radiotherapy, a fundamental treatment modality, has faced challenges such as targeted dose deposition and radiation exposure to healthy tissues, limiting optimal outcomes. To address these hurdles, nanomaterials, specifically gold nanoparticles (AuNPs), [...] Read more.
Cervical cancer remains a pressing global health concern, necessitating advanced therapeutic strategies. Radiotherapy, a fundamental treatment modality, has faced challenges such as targeted dose deposition and radiation exposure to healthy tissues, limiting optimal outcomes. To address these hurdles, nanomaterials, specifically gold nanoparticles (AuNPs), have emerged as a promising avenue. This study delves into the realm of cervical cancer radiotherapy through the meticulous exploration of AuNPs’ impact. Utilizing ex vivo experiments involving cell lines, this research dissected intricate radiobiological interactions. Detailed scrutiny of cell survival curves, dose enhancement factors (DEFs), and apoptosis in both cancer and normal cervical cells revealed profound insights. The outcomes showcased the substantial enhancement of radiation responses in cancer cells following AuNP treatment, resulting in heightened cell death and apoptotic levels. Significantly, the most pronounced effects were observed 24 h post-irradiation, emphasizing the pivotal role of timing in AuNPs’ efficacy. Importantly, AuNPs exhibited targeted precision, selectively impacting cancer cells while preserving normal cells. This study illuminates the potential of AuNPs as potent radiosensitizers in cervical cancer therapy, offering a tailored and efficient approach. Through meticulous ex vivo experimentation, this research expands our comprehension of the complex dynamics between AuNPs and cells, laying the foundation for their optimized clinical utilization. Full article
(This article belongs to the Special Issue Drug Delivery Nanosystems for Biomedical Applications)
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