Impact of Inflammation in Neurodevelopment
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Cellular Biochemistry".
Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 2775
Special Issue Editors
2. Discipline of Psychiatry and Mental Health, Faculty of Medicine, University of New South Wales, Sydney, Australia
3. Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
Interests: neuroinflammation; immunopsychiatry; immune-brain signalling; animal models of neuropsychiatric disease; neurodevelopmental disorders; cognitive impairment; depression; schizophrenia
2. Department of Neuroscience and Physiology, Upstate Medical University, Syracuse, NY, USA
Interests: schizophrenia; neuroinflammation; neuropathology; growth factors; hormones; cytokines; neurodevelopment; post-mortem brain research
Special Issue Information
Dear Colleagues,
Mammalian brain development involves neuronal proliferation, differentiation, apoptosis, migration, neurite formation, axonal wiring, dendritic arborisation, synaptogenesis, and synaptic sculpting. These events are supported by a variety of glial cells and blood vessels, which are themselves undergoing genesis and maturation. This multifaceted process is orchestrated by cell to cell signalling involving many types of molecules including “immune system” communicators. While the bulk of morphological brain changes occur in fetal to early postnatal life, neuromaturation continues well into the postnatal period allowing the external environment to impact brain wiring through one’s experiences. Thus, early life stress and infection can dramatically alter neurodevelopment by modulating “immune” signalling in the body and brain.
In this Special Issue of Biomolecules called “Impact of Inflammation in Neurodevelopment”, we would like to highlight the emerging role of the immune system in normal and abnormal neurodevelopment. Now is the time to address what is known and what remains to be answered with regard to the influence of the immune system on neurodevelopment, including its role in the pathogenesis and pathophysiology of neurodevelopmental disorders. Of particular interest is the more recently accepted role of the immune system in normal neurodevelopment and how it is utilised during critical periods of neurodevelopment across age. We welcome review articles and primary data papers that investigate the role and consequences of inflammation on neurodevelopment from preconception until adulthood. We invite contributions from diverse disciplines including preclinical, post-mortem brain, and epidemiological studies. The topics and scope of review papers should be confirmed with the guest editors prior to submission to avoid redundancy; alternative approaches to review topics may be suggested.
Dr. Adam K. Walker
Prof. Dr. Cynthia Shannon Weickert
Dr. Rachel Sager
Guest Editors
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Keywords
- inflammation
- neuroinflammation
- development
- neurodevelopmental disorders
- neurodevelopment
- cytokines
- complement
- chemokines
- glia
- infection
- maternal immune activation
- neurodevelopment across the life span
- neuron
- peripheral
- stress
- prenatal
- postnatal
- neurogenesis
- synaptogenesis
- synaptic pruning
- programmed cell death
- differentiation
- maturation
- myelination
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