Plant Polyphenols in the Immune and Inflammatory Responses, 2nd Edition 

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-derived Molecules".

Deadline for manuscript submissions: closed (25 August 2024) | Viewed by 1816

Special Issue Editor

Southern Regional Research Center, US Department of Agriculture, New Orleans, LA 70124, USA
Interests: biochemistry and molecular biology of human nutrition and natural products with a focus on plant polyphenols from green tea, cinnamon, and cottonseed; biochemical genetics and metabolic pathways- carbohydrate, lipid, and RNA metabolism; protein/enzyme expression, purification, structure, function, enzymology, and proteomics; signal transduction pathways- insulin, tristetraprolin, and brassinosteroid
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Special Issue Information

Dear Colleagues,

Inflammation and associated immune diseases have placed a heavy burden on the health care system. Drug treatment aimed at reducing inflammation and related diseases has not been satisfactory, and thus complementary and alternative approaches need to be evaluated.

Plant extracts have historically been employed as alternative medicines for the prevention, alleviation, and cure of various diseases. The mechanisms implicated in the action of bioactive plant extracts are poorly understood, due, in part, to a lack of knowledge pertaining to the structures of bioactive components in most extracts.

Plant polyphenols are major bioactive compounds in plant extracts. They are produced by the plant flavonoid biosynthetic pathway and employed naturally as plant defenses against predators. Plant polyphenols are present in most diets and are beneficial to human health. They regulate mammalian gene expression in numerous studies. The anti-inflammatory activities of plant polyphenols are thought to play a vital role in the mediation of various health conditions in these alternative therapies; however, these anti-inflammatory mechanisms are not completely understood.

This Special Issue aims to highlight plant polyphenols in the immune and inflammatory response. Topics include plant polyphenol extraction, identification, bioactivity, the structure–function relationship, and molecular mechanisms at DNA, RNA, protein, and metabolic levels. We welcome comprehensive reviews and original research papers.

Dr. Heping Cao
Guest Editor

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Keywords

  • plant polyphenol
  • bioactivity
  • immunity
  • inflammation
  • molecular mechanism
  • structure-function relationship

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Published Papers (1 paper)

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Research

12 pages, 1541 KiB  
Article
Effect of Flavonols of Aronia melanocarpa Fruits on Morphofunctional State of Immunocompetent Organs of Rats under Cyclophosphamide-Induced Immunosuppression
by Kseniya Bushmeleva, Alexandra Vyshtakalyuk, Dmitriy Terenzhev, Timur Belov, Evgeniy Nikitin and Vladimir Zobov
Biomolecules 2024, 14(5), 578; https://doi.org/10.3390/biom14050578 - 14 May 2024
Viewed by 1369
Abstract
Aronia melanocarpa berries contain many compounds with potential benefits for human health. The food flavonoids quercetin and rutin, found in significant amounts in the fruits of A. melanocarpa, are known to have favourable effects on animal and human organisms. However, data on [...] Read more.
Aronia melanocarpa berries contain many compounds with potential benefits for human health. The food flavonoids quercetin and rutin, found in significant amounts in the fruits of A. melanocarpa, are known to have favourable effects on animal and human organisms. However, data on the effect of flavonols isolated from black chokeberry on immune functions during immunosuppression are not available in the literature. Thus, the aim of this study was to evaluate the effect of flavonol fraction isolated from A. melanocarpa fruits, in comparison with pure quercetin and rutin substances, on the dysfunctional state of rat thymus and spleen in immunodeficiency. The study was performed on Wistar rats. The animals were orally administered solutions of the investigated substances for 7 days: water, a mixture of quercetin and rutin and flavonol fraction of A. melanocarpa. For induction of immunosuppression, the animals were injected once intraperitoneally with cyclophosphamide. Substance administration was then continued for another 7 days. The results showed that under the influence of flavonols, there was a decrease in cyclophosphamide-mediated reaction of lipid peroxidation enhancement and stimulation of proliferation of lymphocytes of thymus and spleen in rats. At that, the effect of the flavonol fraction of aronia was more pronounced. Full article
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