Molecular Mechanisms of Kidney Injury and Repair II
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 2473
Special Issue Editor
Interests: ischemia- and toxicant-induced acute kidney injury; bioenergetics; mitochondrial dysfunction; protein phosphorylation; proteomics; protein kinases; cell injury; mechanisms of cell death
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Kidney disease remains a global public health concern because of high morbidity and mortality, and the significant healthcare costs associated with this disease. Chronic kidney disease gradually leads to a reduced quality of life. Ischemia, hypoxia, exposure to nephrotoxic compounds, and infections are the leading causes of acute kidney injury, which is encountered in a variety of clinical settings and is characterized by a rapid decline in kidney function and the failure to regulate fluids, electrolytes, and the acid–base balance. Evidence collected over the past 2 years suggests that SARS-CoV-2 infection may result in acute kidney injury followed by renal fibrosis. The mechanisms of renal injury caused by SARS-CoV-2 infection are not fully elucidated and could include the direct infection of the kidneys, or indirect mechanisms such as endothelial cell injury, thrombus formation, hypoxia, and changes in the oxidative metabolism of fuels. The signaling pathway originating from ACE2 may play a major role in mediating the acute renal injury caused by SARS-CoV-2.
The pathogenesis of acute kidney injury is associated with a series of cellular responses to the initial insult that involve different pathways and mechanisms, and a large variety of molecular targets. If the injury and stress are not too severe, repair processes are activated to replace lost cells, restore cellular metabolism and functions, and recover kidney functions. If the insult is prolonged or too severe, cellular stress and tissue dysfunction continue and the inflammatory cells are recruited to the kidney, initiating events that lead to inflammation, fibrosis, and eventually the progressive loss of renal function characteristic of chronic kidney disease. Progress made in understanding these complex mechanisms has resulted in the development of new biomarkers to diagnose acute kidney injury and its progression to chronic kidney disease.
Given the success of the first edition, we believe it is time to launch the second edition of this Special Issue. This Special Issue of Biomolecules seeks manuscripts that 1) identify molecular targets that are involved in mediating renal cell injury and/or promoting the repair of these cells after injury; 2) elucidate cellular, subcellular, and molecular mechanisms and pathways mediating kidney repair and recovery; and 3) propose therapeutic interventions to diminish or treat kidney injury or promote kidney recovery. In particular, we would like to encourage the submission of manuscripts that highlight the most recent findings regarding the mechanisms of acute kidney injury caused by SARS-CoV-2 infection and renal complications associated with this infection. We encourage scientists working in this area of research to submit original research articles, communications, and/or critical reviews that synthesize the current literature and discuss emerging directions in this field.
Prof. Dr. Grazyna Nowak
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pathogenesis of acute and chronic kidney injury
- ischemic and/or nephrotoxic kidney injury
- SARS-CoV2-induced kidney injury
- glomerular/interstitial/vascular damage
- different mechanisms of tubular cell death
- inflammatory signals and fibrosis
- bioenergetics, mitochondrial damage and biogenesis
- autophagy and mitophagy
- receptors and signaling pathways involved in kidney injury
- cell cycle proteins
- biomarkers
- renal repair and regeneration
- cytoprotection and therapeutic intervention
- in vivo and in vitro models of kidney injury
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
