Parkinson’s Disease——Honorary Special Issue Commemorating the 80th Birthday of Professor Peter Riederer

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 8385

Special Issue Editors


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Guest Editor
Department of Neurology, Ruhr-Universität Bochum, Bochum, Germany
Interests: Parkinson’s disease; neuron; neuroprotection; neuroregeneration; neuroinflammation; neurodegeneration; biomarkers; protein aggregation; alpha-synuclein; translational therapies
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Guest Editor
Leopoldina Hospital Schweinfurt, Schweinfurt, Germany
Interests: neurological diseases; neurological disorders; clinical neurology; neurodegeneration; movement disorders

Special Issue Information

Dear Colleagues,

This issue is dedicated to the 80th birthday of Professor Dr Peter Riederer.

He is one the most influential experimental researchers in the field of neurochemistry in psychiatry and neurology. His life time achievement is characterised by the continuous successful approach to combine clinical and experimental research.

This honorary issue in “Biomolecules” reflects this scientific principle and includes experimental findings and outcomes of clinical studies.

The editors wish Professor Riederer many further fruitful future years and thank him for his continuous support over the years.

Prof. Dr. Lars Tönges
Prof. Dr. Thomas Müller
Prof. Dr. Wilfried Kuhn
Guest Editors

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Published Papers (1 paper)

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Review

15 pages, 888 KiB  
Review
Update on CSF Biomarkers in Parkinson’s Disease
by Eun Hae Kwon, Sabrina Tennagels, Ralf Gold, Klaus Gerwert, Léon Beyer and Lars Tönges
Biomolecules 2022, 12(2), 329; https://doi.org/10.3390/biom12020329 - 18 Feb 2022
Cited by 35 | Viewed by 7400
Abstract
Progress in developing disease-modifying therapies in Parkinson’s disease (PD) can only be achieved through reliable objective markers that help to identify subjects at risk. This includes an early and accurate diagnosis as well as continuous monitoring of disease progression and therapy response. Although [...] Read more.
Progress in developing disease-modifying therapies in Parkinson’s disease (PD) can only be achieved through reliable objective markers that help to identify subjects at risk. This includes an early and accurate diagnosis as well as continuous monitoring of disease progression and therapy response. Although PD diagnosis still relies mainly on clinical features, encouragingly, advances in biomarker discovery have been made. The cerebrospinal fluid (CSF) is a biofluid of particular interest to study biomarkers since it is closest to the brain structures and therefore could serve as an ideal source to reflect ongoing pathologic processes. According to the key pathophysiological mechanisms, the CSF status of α-synuclein species, markers of amyloid and tau pathology, neurofilament light chain, lysosomal enzymes and markers of neuroinflammation provide promising preliminary results as candidate biomarkers. Untargeted approaches in the field of metabolomics provide insights into novel and interconnected biological pathways. Markers based on genetic forms of PD can contribute to identifying subgroups suitable for gene-targeted treatment strategies that might also be transferable to sporadic PD. Further validation analyses in large PD cohort studies will identify the CSF biomarker or biomarker combinations with the best value for clinical and research purposes. Full article
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