Molecular Basis of Mast Cells Activation and Medical Implications
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 110
Special Issue Editors
Interests: mast cell; immediate hypersensitivity; drug allergy; hereditary angioedema; C1 inhibitor deficiency
Interests: basophils; Hymenoptera venom anaphylaxis; mast cell disorders; hereditary alpha-tryptasemia; hereditary angioedema
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mast cells respond to environmental cues and inflammatory signals. This response translates into complex roles in immunity, tissue homeostasis, and diseases, particularly allergy and hypersensitivity reactions. They are activated through various receptors, including the high-affinity IgE receptor, cytokine receptors, and pattern recognition receptors. Subsequently, intracellular signaling pathways and calcium signaling events lead to mast cell degranulation, mediator release, and the development of a wide range of immediate hypersensitivity medical conditions, from local urticaria to anaphylaxis.
Over the last decade, significant progress has been made in understanding mast cell activation and the regulation mechanisms that may be involved in the development and progression of allergy and hypersensitivity reactions.
The aim of this Special Issue is to highlight recent advances in this field, which may be useful in the prevention of individuals of developing immediate hypersensitivity reactions and in the development of pharmacotherapeutic strategies through the evaluation of novel effective molecular targets.
We encourage researchers who are interested in this topic to submit original research articles that highlight the current preclinical and clinical knowledge on the molecular basis of mast cell activation and implications for the development of mast-cell-driven allergy and hypersensitivity reactions. In addition, critical and systematic review articles covering the relevant research, with concluding remarks and suggestions for future work, will also be considered for inclusion in this Special Issue.
Dr. Grzegorz Porebski
Dr. Matija Rijavec
Guest Editor
Manuscript Submission Information
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Keywords
- mast cells
- allergy
- immediate hypersensitivity
- molecular mechanisms
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