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Biomolecules
Special Issues
Bone Tissue Engineering in Dentistry and the Maxillofacial Region
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Bone Tissue Engineering in Dentistry and the Maxillofacial Region

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 6913

Special Issue Editor

Prof. Dr. Yin Xiao

E-Mail Website
Guest Editor
School of Medicine and Dentistry, Griffith University, Gold Coast, QLD 4222, Australia
Interests: biomaterials; stem cells; tissue engineering; regenerative medicine; inflammation and tissue repair and regeneration; regenerative dentistry; bone and cartilage regeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There is still an unmet clinical need to guide bone tissue regeneration in the treatment of periodontal diseases, dental implants, and maxillofacial reconstruction. Recent progress in bone tissue engineering and regenerative medicine has significantly improved biomaterial development and biofabrication techniques, the understanding of osteoimmunomodulation during tissue regeneration, and the application of nanotechnology and hydrogels for smart materials design. This Special Issue will provide a platform with which to share the advancements in the field of bone tissue engineering in dentistry and the maxillofacial region.

Prof. Dr. Yin Xiao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone
  • regenerative medicine
  • biomaterials

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Published Papers (2 papers)

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Research

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17 pages, 11690 KiB  
Article
Cannabidiol Rescues TNF-α-Inhibited Proliferation, Migration, and Osteogenic/Odontogenic Differentiation of Dental Pulp Stem Cells
by Lina Yu, Liting Zeng, Zeyu Zhang, Guanxiong Zhu, Zidan Xu, Junyi Xia, Jinlong Weng, Jiang Li and Janak Lal Pathak
Biomolecules 2023, 13(1), 118; https://doi.org/10.3390/biom13010118 - 6 Jan 2023
Cited by 12 | Viewed by 3415
Abstract
Strategies to promote dental pulp stem cells (DPSCs) functions including proliferation, migration, pro-angiogenic effects, and odontogenic/osteogenic differentiation are in urgent need to restore pulpitis-damaged dentin/pulp regeneration and DPSCs-based bone tissue engineering applications. Cannabidiol (CBD), an active component of Cannabis sativa has shown anti-inflammation, [...] Read more.
Strategies to promote dental pulp stem cells (DPSCs) functions including proliferation, migration, pro-angiogenic effects, and odontogenic/osteogenic differentiation are in urgent need to restore pulpitis-damaged dentin/pulp regeneration and DPSCs-based bone tissue engineering applications. Cannabidiol (CBD), an active component of Cannabis sativa has shown anti-inflammation, chemotactic, anti-microbial, and tissue regenerative potentials. Based on these facts, this study aimed to analyze the effect of CBD on DPSCs proliferation, migration, and osteogenic/odontogenic differentiation in basal and inflammatory conditions. Highly pure DPSCs with characteristics of mesenchymal stem cells (MSCs) were successfully isolated, as indicated by the results of flowcytometry and multi-lineage (osteogenic, adipogenic, and chondrogenic) differentiation potentials. Among the concentration tested (0.1–12.5 µM), CBD (2.5 μM) showed the highest anabolic effect on the proliferation and osteogenic/odontogenic differentiation of DPSCs. Pro-angiogenic growth factor VEGF mRNA expression was robustly higher in CBD-treated DPSCs. CBD also prompted the migration of DPSCs and CBD receptor CB1 and CB2 expression in DPSCs. TNF-α inhibited the viability, migration, and osteogenic/odontogenic differentiation of DPSCs and CBD reversed these effects. CBD alleviated the TNF-α-upregulated expression of pro-inflammatory cytokines TNF-α, interleukin (IL)-1β, and IL-6 in DPSCs. In conclusion, our results indicate the possible application of CBD on DPSCs-based dentin/pulp and bone regeneration. Full article
(This article belongs to the Special Issue Bone Tissue Engineering in Dentistry and the Maxillofacial Region)
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Review

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31 pages, 5116 KiB  
Review
Polymeric Nanocomposite Hydrogel Scaffolds in Craniofacial Bone Regeneration: A Comprehensive Review
by Maha H. Bashir, Nahed S. Korany, Dina B. E. Farag, Marwa M. S. Abbass, Bassant A. Ezzat, Radwa H. Hegazy, Christof E. Dörfer and Karim M. Fawzy El-Sayed
Biomolecules 2023, 13(2), 205; https://doi.org/10.3390/biom13020205 - 19 Jan 2023
Cited by 13 | Viewed by 2859
Abstract
Nanocomposite biomaterials combine a biopolymeric matrix structure with nanoscale fillers. These bioactive and easily resorbable nanocomposites have been broadly divided into three groups, namely natural, synthetic or composite, based on the polymeric origin. Preparing such nanocomposite structures in the form of hydrogels can [...] Read more.
Nanocomposite biomaterials combine a biopolymeric matrix structure with nanoscale fillers. These bioactive and easily resorbable nanocomposites have been broadly divided into three groups, namely natural, synthetic or composite, based on the polymeric origin. Preparing such nanocomposite structures in the form of hydrogels can create a three-dimensional natural hydrophilic atmosphere pivotal for cell survival and new tissue formation. Thus, hydrogel-based cell distribution and drug administration have evolved as possible options for bone tissue engineering and regeneration. In this context, nanogels or nanohydrogels, created by cross-linking three-dimensional polymer networks, either physically or chemically, with high biocompatibility and mechanical properties were introduced as promising drug delivery systems. The present review highlights the potential of hydrogels and nanopolymers in the field of craniofacial tissue engineering and bone regeneration. Full article
(This article belongs to the Special Issue Bone Tissue Engineering in Dentistry and the Maxillofacial Region)
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