The Role of Angiotensin in Cardiovascular Disease
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".
Deadline for manuscript submissions: closed (20 May 2022) | Viewed by 8906
Special Issue Editors
Interests: I have a strong interest in understanding cardiovascular diseases and metabolic disorders such as diabetes mellitus and dyslipidemia; I have been conducting research to clarify the pathogenic mechanisms of vascular and organ damage, and I am interested in developing novel strategies for prevention and treatment of these damages
Special Issue Information
Dear Colleagues,
The renin angiotensin aldosterone system (RAAS) plays a crucial role in cardiovascular physiology and pathophysiology, by regulating vascular constriction, fluid volume regulation, cell growth, and so on. Angiotensin II (Ang II), the major bioactive peptide of the RAAS, is one of the key players in RAAS, mediating various signal transduction cascades by activating its receptors, such as Ang II type 1 receptor (AT1R) and Ang II type 2 receptor (AT2R). The importance of functional crosstalk between the AngII-AT1R signalling pathway and the other signalling pathways has also been elucidated. Furthermore, accumulating evidence has revealed the role of systemic and local RAAS in cardiovascular diseases (CVDs) in clinical settings, and RAAS is a widely recognized therapeutic target in patients with CVDs. Over the past three decades, many basic and clinical research studies have unveiled the complex role of RAAS in CVDs. However, many questions still remain to be elucidated. Therefore, this Special Issue on “The Role of Angiotensin in Cardiovascular Disease” will include, but is not limited to, the articles investigating the molecular mechanisms of the RAAS in CVDs, translational evaluations on these findings, and in vitro, in vivo and clinical studies examining how the RAAS is involved in cardiovascular and metabolic disorders. This Special Issue also welcomes review articles summarizing up-to-date overviews of recent angiotensin signalling and its functional significance in CVDs.
Prof. Dr. Rosario Scalia
Dr. Tatsuo Kawai
Guest Editors
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Keywords
- Angiotensin II
- RAAS
- Cardiovascular diseases
- AT1
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