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Circulating ncRNAs as Biomarkers in Health and Disease

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A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biomarkers".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 5126

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Special Issue Editor

Dr. Jan Novák

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Guest Editor

1. Second Department of Internal Medicine, St. Anne´s University Hospital in Brno and Faculty of Medicine, Masaryk University, Pekařská 53, 65691 Brno, Czech Republic
2. Central European Institute of Technology, Masaryk University, Kamenice 5, 62500 Brno, Czech Republic
3. Department of Physiology, Masaryk University, Kamenice 5, 62500 Brno, Czech Republic
Interests: microRNA; piRNA; small noncoding RNA; circulating microRNA; biomarker; plasmatic microRNA; urinary microRNA; heart transplantation; acute cellular rejection; cardiac allograft vasculopathy; microRNA-related polymorphisms (SNPs); renin–angiotensin–aldosterone system polymorphisms; deep vein thrombosis; pulmonary embolism; capillaroscopy

Special Issue Information

Dear Colleagues,

I am organizing this Special Issue called “Circulating ncRNAs as Biomarkers in Health and Disease” for the Biomolecules journal. In the last three decades, crucial progress has been achieved regarding our understanding of the roles of intracellular and extracellular noncoding RNAs (ncRNAs). Intracellularly, ncRNAs seem to be necessary regulators of gene expression affecting and modulating the course of diseases. From tissues to extracellular fluid, ncRNAs are actively pumped to act as messengers involved in intercellular communication, or can be passively released, e.g., due to tissue damage, both of which can serve us in clinical practice to better understand, diagnose or estimate the further progression of diseases in our patients. Firstly, many small ncRNAs, such as microRNAs or PIWI-interacting RNAs, have been identified as potential biomarkers of various diseases, following the recent categorization of long ncRNAs. With the recent COVID-19 pandemic, many laboratories throughout the world obtained novel laboratory equipment, allowing them to determine DNA and RNA molecules from samples; thus, I believe an era of novel ncRNA-based biomarkers potentially able to achieve use in daily clinical practice is now ahead of us, and this Special Issue aims to collect both original and review papers focusing on the roles of circulating ncRNAs in health and disease.

Dr. Jan Novák
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

ncRNA
microRNA
lncRNA
biomarkers
circulating

Published Papers (3 papers)

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Research

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16 pages, 4302 KiB

Open AccessArticle

Small Non-Coding RNAs as New Biomarkers to Evaluate the Quality of the Embryo in the IVF Process

by Silvia Toporcerová, Ivana Špaková, Katarína Šoltys, Zuzana Klepcová, Marek Kľoc, Júlia Bohošová, Karolína Trachtová, Lucia Peterová, Helena Mičková, Peter Urdzík, Mária Mareková, Ondřej Slabý and Miroslava Rabajdová

Biomolecules 2022, 12(11), 1687; https://doi.org/10.3390/biom12111687 - 14 Nov 2022

Cited by 2 | Viewed by 2010

Abstract

The increased interest in assisted reproduction through in vitro fertilization (IVF) leads to an urgent need to identify biomarkers that reliably highly predict the success of pregnancy. Despite advances in diagnostics, treatment, and IVF approaches, the 30% success rate of IVF seems insurmountable. Idiopathic infertility does not have any explanation for IVF failure especially when a patient is treated with a healthy competitive embryo capable of implantation and development. Since appropriate intercellular communication is essential after embryo implantation, the emergence of the investigation of embryonic secretome including short non-coding RNA (sncRNA) molecules is crucial. That’s why biomarker identification, sncRNAs secreted during the IVF process into the blastocyst’s cultivation medium, by the implementation of artificial intelligence opens the door to a better understanding of the bidirectional communication between embryonic cells and the endometrium and so the success of the IVF. This study presents a set of promising new sncRNAs which are revealed to predictively distinguish a high-quality embryo, suitable for an embryo transfer in the IVF process, from a low-quality embryo with 86% accuracy. The identified exact combination of miRNAs/piRNAs as a non-invasively obtained biomarker for quality embryo determination, increasing the likelihood of implantation and the success of pregnancy after an embryo transfer. Full article

(This article belongs to the Special Issue Circulating ncRNAs as Biomarkers in Health and Disease)

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11 pages, 688 KiB

Open AccessArticle

MiR-223 and MiR-186 Are Associated with Long-Term Mortality after Myocardial Infarction

by Meyer Elbaz, Julien Faccini, Clémence Laperche, Marie-Hélène Grazide, Jean-Bernard Ruidavets and Cécile Vindis

Biomolecules 2022, 12(9), 1243; https://doi.org/10.3390/biom12091243 - 6 Sep 2022

Cited by 6 | Viewed by 1490

Abstract

Background—The identification and stratification of patients at risk of fatal outcomes after myocardial infarction (MI) is of considerable interest to guide secondary prevention therapies. Currently, no accurate biomarkers are available to identify subjects who are at risk of suffering acute manifestations of coronary heart disease as well as to predict adverse events after MI. Non-coding circulating microRNAs (miRNAs) have been proposed as novel diagnostic and prognostic biomarkers in cardiovascular diseases. The aims of the study were to investigate the clinical value of a panel of circulating miRNAs as accurate biomarkers associated with MI and mortality risk prediction in patients with documented MI. Methods and Results—seven circulating plasma miRNAs were analyzed in 67 MI patients and 80 control subjects at a high cardiovascular risk but without known coronary diseases. Multivariate logistic regression analyses demonstrated that six miRNAs were independently associated with MI occurrence. Among them, miR-223 and miR-186 reliably predicted long-term mortality in MI patients, in particular miR-223 (HR 1.57 per one-unit increase, p = 0.02), after left ventricular ejection fraction (LVEF) adjustment. Kaplan–Meier survival analyses provided a predictive threshold value of miR-223 expression (p = 0.028) for long-term mortality. Conclusions—Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI. Full article

(This article belongs to the Special Issue Circulating ncRNAs as Biomarkers in Health and Disease)

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Review

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33 pages, 3239 KiB

Open AccessReview

LncRNAs and CircRNAs as Strategies against Pathological Conditions Caused by a Hypoxic/Anoxic State

by Ivan Anchesi, Giovanni Schepici and Emanuela Mazzon

Biomolecules 2023, 13(11), 1622; https://doi.org/10.3390/biom13111622 - 6 Nov 2023

Cited by 1 | Viewed by 1043

Abstract

Brain damage can be induced by oxygen deprivation. It is known that hypoxic or anoxic conditions can lead to changes in the expression levels of non-coding RNAs (ncRNAs), which, in turn, can be related to Central Nervous System (CNS) injuries. Therefore, it could be useful to investigate the involvement of non-coding RNAs (ncRNAs), as well as the underlying mechanisms which are able to modulate them in brain damage induced by hypoxic or anoxic conditions. In this review, we focused on recent research that associates these conditions with long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs). The results of this review demonstrate that the expression of both lncRNAs and circRNAs can be influenced by oxygen deprivation conditions and so they can contribute to inducing damage or providing neuroprotection by affecting specific molecular pathways. Furthermore, several experimental studies have shown that ncRNA activity can be regulated by compounds, thus also modifying their transcriptomic profile and their effects on CNS damages induced by hypoxic/anoxic events. Full article

(This article belongs to the Special Issue Circulating ncRNAs as Biomarkers in Health and Disease)

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