Advances in S-Triazine-Based Therapeutics: From Antimicrobials to Neurodegenerative Disease Modulators
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 1420
Special Issue Editor
Interests: organic synthesis; anticancer drug; trimethoprim derivatives; s-triazine derivatives; netropsin and distamycin analogues; antimicrobials; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
1,3,5-Triazine, known as s-triazine, is one of the oldest heterocyclic compounds available, and due to its low cost and high availability, it has continually attracted the attention of scientists who aim to synthesize and investigate the activity of its new derivatives.
Nucleophilic substitution in the s-triazine ring is favored over electrophilic substitution due to its lower basicity and much weaker resonance energy than that of benzene. Thus, a number of heterocyclic compounds with a symmetric s-triazine core have been obtained, which represent an interesting class of compounds with a wide spectrum of biological properties. Among them, triazine is not only a core, but also a factor that increases the kinetic potential of the whole derivatives. In medicinal chemistry, the most interesting derivatives to date have been those with anticancer, antiviral, antimicrobial, or antimalarial activity. Recently, however, derivatives with activity against agents in other clinical problems, such as neurodegenerative diseases, have also been obtained.
This Special Issue focuses on recent developments in the design, synthesis, and activity testing of new s-triazine derivatives, as well as new molecular targets for these compounds. Literature reviews summarizing knowledge from various studies on s-triazine and its derivatives are also welcome for publication.
Dr. Danuta Drozdowska
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- 1,3,5-triazine
- s-triazine
- biological activity
- drug discovery
- antibacterial agent
- antifungal agent
- anticancer activity
- antiviral agents
- antimalarial activity
- anti-Alzheimer’s activity
- anti-Alzheimer’s agents
- cholinesterase inhibitors
- BACE1 inhibitors
- anti-neurodegenerative effects
- anti-inflammatory activity
- molecular mechanisms of s-triazine activity
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
