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Biomolecules
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The Road to End-Stage Liver Disease: From Function Dysregulation to...
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The Road to End-Stage Liver Disease: From Function Dysregulation to Architecture Remodeling

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 10847

Special Issue Editor

Dr. Honglei Weng

E-Mail Website
Guest Editor
Department of Medicine II, Section Molecular Hepatology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Interests: End-stage liver disease; liver regeneration; signaling and transcriptional regulation

Special Issue Information

Dear Colleagues,

Although there are a large number of initiating factors, the end results of liver diseases are few. Acute or chronic liver failure and portal hypertension are the two main pathophysiological alterations and clinical syndrome corresponding to the end-stage liver disease. From initiating damage to end-stage liver disease, the liver undergoes a series of functional and architectural changes, including parenchymal cell death, dysregulated immune response, failed wound healing (fibrosis), insufficient regeneration, and a distorted vascular system. Intercross different disease initiating factors lead to these severe outcomes through different mechanisms, which are relevant to different live cells, inflammatory factors, and signaling. Clarification of these mechanisms is essential and critical to understand how a healthy liver goes to disease end point.

This Special Issue entitled “The Road to End-Stage Liver Disease: From Function Dysregulation to Architecture Remodeling” provides a platform that highlights the current understanding of several crucial aspects contributing to the progress from liver damage to end-stage liver disease. The topic collection also focuses on the controversial issues relevant to wound healing, vascular remodeling, liver regeneration, and liver failure.

Dr. Honglei Weng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • End-stage liver disease
  • Liver failure
  • Liver regeneration
  • Portal hypertension
  • Vascular remodeling

Published Papers (3 papers)

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Review

16 pages, 2240 KiB  
Review
Gut Microbiota Regulation of AHR Signaling in Liver Disease
by Baohong Wang, Ziyuan Zhou and Lanjuan Li
Biomolecules 2022, 12(9), 1244; https://doi.org/10.3390/biom12091244 - 6 Sep 2022
Cited by 8 | Viewed by 3193
Abstract
Liver health plays a vital role in human health and disease. Emerging evidence has shown the importance of the aryl hydrocarbon receptor (AHR) in liver diseases such as alcoholic liver disease, fatty liver disease, and liver failure. As a ligand-activated transcription factor, AHR [...] Read more.
Liver health plays a vital role in human health and disease. Emerging evidence has shown the importance of the aryl hydrocarbon receptor (AHR) in liver diseases such as alcoholic liver disease, fatty liver disease, and liver failure. As a ligand-activated transcription factor, AHR can be activated by endogenous ligands of microbial metabolites such as tryptophan (Trp), kynurenine (Kyn) or indole derivatives locally or distantly. However, the therapeutic effects of the gut microbiota-regulated AHR pathway remain to be clarified. In this review, we summarize recent progress and examine the role of AHR signaling as a target for gut microbiota intervention in liver diseases. The focus on AHR signaling will identify a promising target in the gut microbiota for better understanding and therapeutic opportunities in liver diseases. Full article
(This article belongs to the Special Issue The Road to End-Stage Liver Disease: From Function Dysregulation to Architecture Remodeling)
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10 pages, 594 KiB  
Review
Liver Progenitor Cells in Massive Hepatic Necrosis—How Can a Patient Survive Acute Liver Failure?
by Tao Lin, Rilu Feng, Roman Liebe and Hong-Lei Weng
Biomolecules 2022, 12(1), 66; https://doi.org/10.3390/biom12010066 - 2 Jan 2022
Cited by 3 | Viewed by 2436
Abstract
Massive hepatic necrosis is the most severe lesion in acute liver failure, yet a portion of patients manage to survive and recover from this high-risk and harsh disease syndrome. The mechanisms underlying recovery remain largely unknown to date. Recent research progress highlights a [...] Read more.
Massive hepatic necrosis is the most severe lesion in acute liver failure, yet a portion of patients manage to survive and recover from this high-risk and harsh disease syndrome. The mechanisms underlying recovery remain largely unknown to date. Recent research progress highlights a key role of liver progenitor cells, the smallest biliary cells, in the maintenance of liver homeostasis and thus survival. These stem-like cells rapidly proliferate and take over crucial hepatocyte functions in a severely damaged liver. Hence, the new findings not only add to our understanding of the huge regenerative capability of the liver, but also provide potential new targets for the pharmacological management of acute liver failure in clinical practice. Full article
(This article belongs to the Special Issue The Road to End-Stage Liver Disease: From Function Dysregulation to Architecture Remodeling)
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12 pages, 607 KiB  
Review
Liver Regeneration and Cell Transplantation for End-Stage Liver Disease
by Yan Li, Lungen Lu and Xiaobo Cai
Biomolecules 2021, 11(12), 1907; https://doi.org/10.3390/biom11121907 - 20 Dec 2021
Cited by 14 | Viewed by 4361
Abstract
Liver transplantation is the only curative option for end-stage liver disease; however, the limitations of liver transplantation require further research into other alternatives. Considering that liver regeneration is prevalent in liver injury settings, regenerative medicine is suggested as a promising therapeutic strategy for [...] Read more.
Liver transplantation is the only curative option for end-stage liver disease; however, the limitations of liver transplantation require further research into other alternatives. Considering that liver regeneration is prevalent in liver injury settings, regenerative medicine is suggested as a promising therapeutic strategy for end-stage liver disease. Upon the source of regenerating hepatocytes, liver regeneration could be divided into two categories: hepatocyte-driven liver regeneration (typical regeneration) and liver progenitor cell-driven liver regeneration (alternative regeneration). Due to the massive loss of hepatocytes, the alternative regeneration plays a vital role in end-stage liver disease. Advances in knowledge of liver regeneration and tissue engineering have accelerated the progress of regenerative medicine strategies for end-stage liver disease. In this article, we generally reviewed the recent findings and current knowledge of liver regeneration, mainly regarding aspects of the histological basis of regeneration, histogenesis and mechanisms of hepatocytes’ regeneration. In addition, this review provides an update on the regenerative medicine strategies for end-stage liver disease. We conclude that regenerative medicine is a promising therapeutic strategy for end-stage liver disease. However, further studies are still required. Full article
(This article belongs to the Special Issue The Road to End-Stage Liver Disease: From Function Dysregulation to Architecture Remodeling)
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