New Insights into Metabotropic Glutamate Receptors
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 30
Special Issue Editor
Interests: molecular neuropharmacology; cellular and preclinical models of CNS disorders; metabotropic glutamate receptors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabotropic glutamate (mGlu) receptors were discovered 40 years ago (Sladeczek et al., Nature, 1985), and since the cloning of the first mGlu receptor subtype (Masu et al., Nature, 1991), they have attracted the interest of neuroscientists, with an impressive number (>11400) of research and review articles being published. Subtype-selective mGlu receptor ligands (either orthosteric or allosteric ligands) are promising in the treatment of neurological and psychiatric disorders, such as schizophrenia, major depressive disorder, autism spectrum disorder, Parkinson’s disease, stroke, drug addiction, and chronic pain. A few drugs have advanced to phase 2 of clinical development, but none of them have been marketed so far. The clinical genetics of mGlu receptors have also progressed considerably, with variants of GRM3 and GRM7 (the genes encoding the mGlu3 and mGlu7 subtypes) being associated with schizophrenia and developmental delay, respectively. Another aspect of potential clinical interest is the association between autoimmune encephalitis and antibodies directed against mGlu1 and mGlu5 receptors. Although mGlu receptors have been extensively studied in neurons, they are also present in astrocytes, oligodendrocytes, microglia, cells of peripheral organs, immune cells, and stem/progenitor cells. mGlu1 and mGlu3 receptors have been linked to the pathophysiology of malignant melanomas and malignant gliomas, respectively, and mGlu5 receptor blockade holds promise in the treatment of liver disorders. All this will be discussed at the 11th International Meeting on Metabotropic Glutamate Receptors (Taormina, Italy, October 5, 2024) (https://www.mglu.it/) and the Satellite Meeting (September 30, Taormina, Italy, 2024). This Meeting will be the launch platform for this Special Issue (SI), entitled “New Insights into Metabotropic Glutamate Receptors”. This Special Issue aims to incorporate research articles, review articles, position papers, and viewpoints.
Prof. Dr. Ferdinando Nicoletti
Guest Editor
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Keywords
- metabotropic glutamate receptors
- mGlu receptors
- psychopharmacology
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