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Biomolecules
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Polyamines in the Central Nervous System: Neurons, Glial Cells and...
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Polyamines in the Central Nervous System: Neurons, Glial Cells and Diseases 2.0

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (1 April 2024) | Viewed by 1551

Special Issue Editors

Dr. Serguei Skatchkov

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Guest Editor
School of Medicine, Universidad Central del Caribe, Bayamon, PR, USA
Interests: polyamines and their accumulation in astrocytes; radial glial (Müller, Bergmann) cells; polyamine regulated channels; gap junctions and hemichannels; glia-neuron signaling; gliotransmitters; agmatine; synaptic plasticity; electrophysiology; biochemistry; polyamine function in the brain in health and polyamine-associated diseases and syndromes
Special Issues, Collections and Topics in MDPI journals
Dr. Rüdiger W. Veh

E-Mail Website
Guest Editor
Institut für Zell- und Neurobiologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany
Interests: polyamines and their accumulation in astrocytes; radial glial (Müller, Bergmann) cells; polyamine regulated channels; gap junctions and hemichannels; glia-neuron signaling; gliotransmitters; agmatine; synaptic plasticity; electrophysiology; biochemistry; polyamine function in the brain in health and polyamine-associated diseases and syndromes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polyamines contribute to the pathogenesis of Alzheimer’s, Parkinson’s, and other diseases of the central nervous system (CNS), while polyamine supplementation induces the regeneration of neurons and increases longevity. In the normal adult CNS, the polyamines spermidine and spermine are accumulated preferentially in astrocytic cells, not in neurons, and are key molecules regulating many receptors and channels. Recent evidence emphasizes that the localization of polyamines; their metabolites, including agmatine; and their biosynthetic enzymes in the CNS (brain and retina) vary with age and are altered in diseases. This Special Issue will highlight the uneven functional distribution of polyamines in the CNS, their effects on channels and transporters, as well as their roles in CNS disorders. We invite investigators to contribute high-quality original research and review articles focused on the roles of polyamines in health and disease, concerning the biological functions of neurons, gliotransmission, and the importance in the glial system.

Dr. Serguei Skatchkov
Dr. Rüdiger W. Veh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • astrocytes
  • polyamines
  • spermine
  • spermidine
  • agmatine
  • gliotransmitters and receptors
  • channels
  • diseases
  • syndromes

Related Special Issue

Published Papers (1 paper)

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Research

14 pages, 1868 KiB  
Article
As Verified with the Aid of Biotinylated Spermine, the Brain Cannot Take up Polyamines from the Bloodstream Leaving It Solely Dependent on Local Biosynthesis
by Torsten Weiss, René Bernard, Gregor Laube, Julian Rieck, Misty J. Eaton, Serguei N. Skatchkov and Rüdiger W. Veh
Biomolecules 2023, 13(7), 1114; https://doi.org/10.3390/biom13071114 - 13 Jul 2023
Cited by 3 | Viewed by 1232
Abstract
The importance of polyamines (PAs) for the central nervous system (CNS) is well known. Less clear, however, is where PAs in the brain are derived from. Principally, there are three possibilities: (i) intake by nutrition, release into the bloodstream, and subsequent uptake from [...] Read more.
The importance of polyamines (PAs) for the central nervous system (CNS) is well known. Less clear, however, is where PAs in the brain are derived from. Principally, there are three possibilities: (i) intake by nutrition, release into the bloodstream, and subsequent uptake from CNS capillaries, (ii) production by parenchymatous organs, such as the liver, and again uptake from CNS capillaries, and (iii) uptake of precursors, such as arginine, from the blood and subsequent local biosynthesis of PAs within the CNS. The present investigation aimed to unequivocally answer the question of whether PAs, especially the higher ones like spermidine (SPD) and spermine (SPM), can or cannot be taken up into the brain from the bloodstream. For this purpose, a biotin-labelled analogue of spermine (B-X-SPM) was synthesized, characterized, and used to visualize its uptake into brain cells following application to acute brain slices, to the intraventricular space, or to the bloodstream. In acute brain slices there is strong uptake of B-X-SPM into protoplasmic and none in fibrous-type astrocytes. It is also taken up by neurons but to a lesser degree. Under in vivo conditions, astrocyte uptake of B-X-SPM from the brain interstitial fluid is also intense after intraventricular application. In contrast, following intracardial injection, there is no uptake from the bloodstream, indicating that the brain is completely dependent on the local synthesis of polyamines. Full article
(This article belongs to the Special Issue Polyamines in the Central Nervous System: Neurons, Glial Cells and Diseases 2.0)
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