Protein Kinases (PTKs) in Health and Diseases
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 12603
Special Issue Editor
Special Issue Information
Dear Colleagues,
Through controlling the phosphorylation status of their targets, protein kinases and phosphatases play major roles in a myriad of cellular and extracellular processes such as transcription, cell cycle progression, differentiation, secretion, and apoptosis. Protein phosphorylation is also a key part of the protein–protein interactome as many protein–protein interactions are mediated by phosphorylated Tyr-, Ser- and Thr-based motifs. Therefore, tight and precise regulation of protein phosphorylation and dephosphorylation is critical for the survival of cells, and its dysregulation often leads to disease. For example, the kinases LRRK2, PKB/Akt, c-Abl, cdk5, and GSK-3b have been implicated in the pathogenesis of Parkinson's disease; mTOR, Raf, BCR-Abl, MEK, p38 MAPK, EGFR, and many others have been shown to be involved in cancer; aberrant ASK1 kinase signaling participates in neurodegenerative disorders, inflammatory diseases, and cancer; and the activity of JAK kinases plays crucial roles in autoimmune diseases including rheumatoid arthritis. Thus, a deep understanding of the kinase activity regulations under both healthy and diseased states is necessary for the development of successful therapeutic strategies.
This Special Issue of Biomolecules titled “Protein Kinases (PTKs) in Health and Diseases” will present a collection of recent findings and review articles on the following topics:
- Novel approaches in kinase inhibitor development;
- Correlations between dysregulated protein kinases and diseases;
- Regulation of protein kinase activity through protein–protein interactions.
Prof. Tomas Obsil
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- protein kinase
- kinase inhibitor
- protein–protein interaction
- Parkinson’s disease
- cancer
- inflammation
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
