Protein Kinases (PTKs) in Health and Diseases
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 12883
Special Issue Editor
Special Issue Information
Dear Colleagues,
Through controlling the phosphorylation status of their targets, protein kinases and phosphatases play major roles in a myriad of cellular and extracellular processes such as transcription, cell cycle progression, differentiation, secretion, and apoptosis. Protein phosphorylation is also a key part of the protein–protein interactome as many protein–protein interactions are mediated by phosphorylated Tyr-, Ser- and Thr-based motifs. Therefore, tight and precise regulation of protein phosphorylation and dephosphorylation is critical for the survival of cells, and its dysregulation often leads to disease. For example, the kinases LRRK2, PKB/Akt, c-Abl, cdk5, and GSK-3b have been implicated in the pathogenesis of Parkinson's disease; mTOR, Raf, BCR-Abl, MEK, p38 MAPK, EGFR, and many others have been shown to be involved in cancer; aberrant ASK1 kinase signaling participates in neurodegenerative disorders, inflammatory diseases, and cancer; and the activity of JAK kinases plays crucial roles in autoimmune diseases including rheumatoid arthritis. Thus, a deep understanding of the kinase activity regulations under both healthy and diseased states is necessary for the development of successful therapeutic strategies.
This Special Issue of Biomolecules titled “Protein Kinases (PTKs) in Health and Diseases” will present a collection of recent findings and review articles on the following topics:
- Novel approaches in kinase inhibitor development;
- Correlations between dysregulated protein kinases and diseases;
- Regulation of protein kinase activity through protein–protein interactions.
Prof. Tomas Obsil
Guest Editor
Manuscript Submission Information
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Keywords
- protein kinase
- kinase inhibitor
- protein–protein interaction
- Parkinson’s disease
- cancer
- inflammation
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