Role of Matrix Metalloproteinase in Health and Disease
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: 15 November 2024 | Viewed by 64
Special Issue Editor
Special Issue Information
Dear Colleagues,
Matrix metalloproteinases (MMPs) are a diverse group of secreted and membrane-anchored endopeptidases that play essential roles primarily in maintaining the structural and functional integrity of extracellular matrices, with secondary roles in modulating the action of growth factors, cell surface receptors, cytokines, and chemokines, and thereby affecting signalling pathways. Abnormalities in the regulation and activity of MMPs have been associated with the ageing process and involvement in diseases such as cancers, cardiovascular and peripheral vascular diseases, inflammation, and neurodegenerative diseases such as age-related macular degeneration and Alzheimer’s.
Recent advances in the regulatory aspects of MMP activation, the compartmentalization between bound and free forms, and the post-translation modifications of both the enzyme and their substrates shed light on the underlying mechanisms operational in pathological circumstances, leading to their nomination as likely targets for therapeutic interventions.
This Special Issue of Biomolecules focuses on the role of MMPs in the aetiology and progression of pathological processes and the potential for therapeutic intervention targeting these enzymes. Original manuscripts and review articles addressing the role of MMPs in normal and pathological processes are most welcome.
Dr. Ali A. Hussain
Guest Editor
Manuscript Submission Information
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Keywords
- matrix metalloproteinases (MMPs)
- regulatory aspects of MMPs
- MMPs and tissue ageing
- MMPs in diseases
- MMPs as therapeutic targets
