Pathogenesis and Neuropathology of Alzheimer's Disease
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 1756
Special Issue Editors
Interests: HIV; NeuroAIDS; CRISPR gene-editing; Alzheimer’s disease; nanotechnology
Special Issues, Collections and Topics in MDPI journals
Interests: mitochondrial fragmentation; mitochondria-ER contacts; neurological disorders; RNA m6A modification; neuron-glia crosstalk
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alzheimer’s disease (AD) is the most common form of dementia and the leading neurodegenerative disorder worldwide. It typically manifests as a decline in short-term memory and cognitive abilities, impairing daily functioning. While most AD cases are sporadic, a few hereditary forms have been identified, providing important genetic and neuropathological insights into its broader causes. The disease is characterized by synaptic loss and neuronal shrinkage, particularly in the hippocampus and cerebral cortex. Hallmarks of AD include amyloid plaques and neurofibrillary tau tangles—misfolded protein clumps scattered throughout the brain. Other pathological features of AD comprise abnormal microvasculature, mitochondrial dysfunction, interneuronal dysfunction, increased inflammatory response, elevated production of reactive oxygen species, impaired brain metabolism, dysregulated gene expression, etc. Alzheimer's disease is projected to become a significant public health crisis, and without effective interventions, it will impose considerable personal and economic burdens. Investigating the pathogenesis of AD is critical to identifying therapeutic targets that could lead to disease-modifying treatments. Neuropathological studies of presymptomatic or early symptomatic mutation carriers may offer valuable insights into the etiology of Alzheimer’s disease, similar to other neurodegenerative conditions.
The following Special Issue will explore the neuropathology of Alzheimer’s disease and present new insights into its pathogenesis. We will also showcase exceptional studies investigating predisposing factors leading to neuropathology and identifying early diagnostic markers and methods for AD diagnosis. We hope that this Special Issue will foster a deeper understanding of AD’s pathogenesis, early detection, and possible interventions.
Dr. Venkata Atluri
Dr. Fanpeng Zhao
Guest Editors
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Keywords
- Alzheimer disease
- pathogenesis
- neuropathology
- diagnosis
- neurodegenerative diseases
- microRNA as diagnostic marker
- the important modulatory action of DNA repair enzyme DNA-PKcs in synaptic plasticity
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