The Role of Tumour Microenvironment in Therapeutic Resistance

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 4372

Special Issue Editor


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Guest Editor
Centre for Tumour Microenvironment, Barts Cancer Institute - a Cancer Research UK Centre of Excellence
, Queen Mary University of London, London, UK
Interests: breast cancer; tumour microenvironment; tumour-associated macrophages; extracellular vesicles; therapy resistance

Special Issue Information

Dear Colleagues,

Despite a multitude of treatment advances, cancer remains one of the leading causes of death. There is still a dire need to identify novel therapeutic targets, enhance responses to current treatments and overcome resistance. The tumour microenvironment consists of non-cancerous cells, namely stromal cells, that interact with the malignant cells and has an instrumental role in promoting tumour growth through diverse mechanisms including, but not limited to, angiogenesis and immunosuppression. Understanding the crosstalk between cancer cells and stromal cells and elucidating its impact on the therapeutic response are crucial elements for identifying new treatment strategies. This Special Issue will highlight a selection of novel and promising discoveries that exploit the tumour microenvironment to control cancer growth and spread and overcome resistance to anti-cancer therapies. 

Dr. Ioanna Keklikoglou
Guest Editor

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Keywords

  • Tumour microenvironment
  • Angiogenesis
  • Inflammation
  • Extracellular matrix

Published Papers (1 paper)

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Review

40 pages, 3435 KiB  
Review
Extracellular Vesicles as Mediators of Therapy Resistance in the Breast Cancer Microenvironment
by Mark Samuels, Chiara Cilibrasi, Panagiotis Papanastasopoulos and Georgios Giamas
Biomolecules 2022, 12(1), 132; https://doi.org/10.3390/biom12010132 - 14 Jan 2022
Cited by 6 | Viewed by 3650
Abstract
Resistance to various therapies, including novel immunotherapies, poses a major challenge in the management of breast cancer and is the leading cause of treatment failure. Bidirectional communication between breast cancer cells and the tumour microenvironment is now known to be an important contributor [...] Read more.
Resistance to various therapies, including novel immunotherapies, poses a major challenge in the management of breast cancer and is the leading cause of treatment failure. Bidirectional communication between breast cancer cells and the tumour microenvironment is now known to be an important contributor to therapy resistance. Several studies have demonstrated that crosstalk with the tumour microenvironment through extracellular vesicles is an important mechanism employed by cancer cells that leads to drug resistance via changes in protein, lipid and nucleic acid cargoes. Moreover, the cargo content enables extracellular vesicles to be used as effective biomarkers for predicting response to treatments and as potential therapeutic targets. This review summarises the literature to date regarding the role of extracellular vesicles in promoting therapy resistance in breast cancer through communication with the tumour microenvironment. Full article
(This article belongs to the Special Issue The Role of Tumour Microenvironment in Therapeutic Resistance)
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