Molecular Mechanisms of Drug Resistance in Breast Cancer
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 1 March 2025 | Viewed by 334
Special Issue Editor
Interests: breast cancer; mechanism of drug resistance; novel therapeutic targets; precision oncology; novel treatment strategies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metastatic breast carcinoma is the second most common cause of death due to cancer and remains incurable. Recently, major advances have been made in the treatment landscape of breast cancer. Cyclin-dependent kinase inhibitors, CDK4/6i, have revolutionized estrogen receptor-positive (ER+) breast cancer therapy. The introduction of two major antibody–drug conjugates (ADCs), trastuzumab deruxtecan and sacituzumab govitecan, has resulted in significant improvements in overall survival in all three subtypes of metastatic breast cancer, and in luminal and triple-negative metastatic breast cancer (TNBC), respectively. The success of immune checkpoint therapies in TNBC has emphasized the importance of the immune system in breast cancer. Despite these advances, resistance to therapy and recurrence/metastasis resulting in death are still a clinical reality. The absence of robust biomarkers for patient selection and inadequate understanding of resistance mechanisms are major barriers to efficacious therapeutics. The cross-talk and heterogeneity of the tumor–tumor microenvironment further add to the complexity of understanding the mechanisms of resistance. There is a crucial need for novel approaches to dissect the mechanisms of drug resistance and alleviate morbidity and mortality in breast cancer. This Special Issue will discuss the evolving landscape of breast cancer therapies and focus on new discoveries as potential mechanisms of resistance to these therapies.
Dr. Yesim Gokmen-Polar
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- breast cancer
- mechanism of resistance
- targeted therapy resistance
- ER+
- HER2
- TNBC
- tumor microenvironment
- recurrence
- metastasis
- tumor evasion
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
