Molecular and Cell Biology in Endometriosis and Endometrial Cancer: Volume 2

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: 15 October 2024 | Viewed by 429

Special Issue Editor


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Guest Editor
Department Of Obstetrics And Gynaecology, Royal Women’s Hospital, University of Melbourne, Parkville, VIC 3052, Australia
Interests: uterine disease; endometriosis; endometrial cancer; molecular pathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following a very successful first run, we are pleased to announce the launch of a second edition of a Special Issue, focusing on Molecular and Cell Biology in Endometriosis and Endometrial Cancer.

The endometrium has been a subject of intense research in a variety of clinical settings due to its importance in the reproductive process and its roles in women’s health. Under the exposure of different risk factors in a woman’s lifetime, normal endometrial tissue can give rise to multiple pathologic conditions, including endometriosis and endometrial cancer. Although methods for the diagnosis of endometriosis and endometrial cancer are well developed in modern gynecology, the underlying etiology and pathophysiologic changes remain largely unclear.

The focus of this Biomolecules Special Issue is on the molecular and cellular mechanisms of endometriosis and endometrial cancer. Areas to be covered in this Special Issue may include, but are not limited to, the molecular pathophysiology of endometriosis and endometrial cancer, genetic and epigenetic changes in endometriosis, endometrial stem/progenitor cells, the molecular basis for a specific therapeutic approach, and molecular biomarkers for endometriosis and endometrial cancer. We would also like to extend this volume, focusing also on the newest technologies used to characterize and analyze female reproductive tissues, such as single cell and spatial transcriptomics, epigenomics, proteomics, metabolomics, and multiomics.

This Special Issue will provide novel information regarding the abovementioned topics, and will be of interest to scientists and clinicians already working on or seeking to understand the molecular and cell biology of endometriosis and endometrial cancer. Therefore, contributions from experts in the field, in the form of original research papers and reviews, are most welcome.

Dr. Jacqueline F. Donoghue
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometriosis
  • endometrial cancer
  • ovarian cancer
  • molecular basis of endometriosis and endometrial cancer
  • single cell transcriptomics
  • spatial transcriptomics
  • multiomics
  • genomics
  • proteomics
  • epigenomics
  • metabolomics

Related Special Issue

Published Papers (1 paper)

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Research

19 pages, 1952 KiB  
Article
Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study
by Natalia Starodubtseva, Vitaliy Chagovets, Alisa Tokareva, Madina Dumanovskaya, Eugenii Kukaev, Anastasia Novoselova, Vladimir Frankevich, Stanislav V. Pavlovich and Gennady Sukhikh
Biomolecules 2024, 14(8), 899; https://doi.org/10.3390/biom14080899 - 24 Jul 2024
Viewed by 252
Abstract
Endometriosis is a prevalent chronic inflammatory disease characterized by a considerable delay between initial symptoms and diagnosis through surgery. The pressing need for a timely, non-invasive diagnostic solution underscores the focus of current research efforts. This study examines the diagnostic potential of the [...] Read more.
Endometriosis is a prevalent chronic inflammatory disease characterized by a considerable delay between initial symptoms and diagnosis through surgery. The pressing need for a timely, non-invasive diagnostic solution underscores the focus of current research efforts. This study examines the diagnostic potential of the menstrual blood lipidome. The lipid profile of 39 samples (23 women with endometriosis and 16 patients in a control group) was acquired using reverse-phase high-performance liquid chromatography–mass spectrometry with LipidMatch processing and identification. Profiles were normalized based on total ion counts. Significant differences in lipids were determined using the Mann–Whitney test. Lipids for the diagnostic model, based on logistic regression, were selected using a combination of variance importance projection filters and Akaike information criteria. Levels of ceramides, sphingomyelins, cardiolipins, triacylglycerols, acyl- and alkenyl-phosphatidylethanolamines, and alkenyl-phosphatidylcholines increased, while acyl- and alkyl-phosphatidylcholines decreased in cases of endometriosis. Plasmenylphosphatidylethanolamine PE P-16:0/18:1 and cardiolipin CL 16:0_18:0_22:5_22:6 serve as marker lipids in the diagnostic model, exhibiting a sensitivity of 81% and specificity of 85%. The diagnostic approach based on dried spots of menstrual blood holds promise as an alternative to traditional non-invasive methods for endometriosis screening. Full article
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