Novel Insights into Choline and Choline Transporters in Human Diseases
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".
Deadline for manuscript submissions: closed (20 August 2023) | Viewed by 251
Special Issue Editor
Interests: molecular pharmacology; choline transporters; oncology; neuroscience
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Choline is a water-soluble quaternary amine and is an essential biofactor for maintaining normal health. It is a component of cell membranes such as phosphatidylcholine and sphingomyelin and plays a role as a precursor of betaine, a methyl donor, and acetylcholine, a neurotransmitter. Choline is consumed in the diet and insufficient intake may cause choline deficiency, especially under conditions that require large amounts of choline, such as pregnancy, breastfeeding, and parenteral nutrition. Choline deficiency affects the expression of genes involved in cell proliferation, differentiation, and apoptosis, as well as central cholinergic nerve function, and has been linked to liver dysfunction, dementia, and cancer. The intracellular transport system of choline is an important function of the rate-limiting step of the choline metabolic system. The choline transport system has been categorized into three transporter families. They include (I) high-affinity choline transporter 1, (II) choline transporter-like proteins, and (III) organic cation transporters. They are expressed in different organisms and cell types, and this implies their importance for choline transport for broader purposes, such as acetylcholine and phospholipid synthesis. Therefore, studies of the properties of the choline metabolic system and choline transporters in various diseases will lead to an understanding of these diseases and the development of novel therapies. This Special Issue focuses on the latest research on the pathophysiology of choline deficiency and its relationship to various diseases, and on the role of choline transporters in the pathophysiology and development of drugs as therapeutic targets. Authors are invited to submit original research and review papers addressing the topic of this Special Issue.
Prof. Dr. Masato Inazu
Guest Editor
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Keywords
- choline transporters
- choline deficiency
- choline metabolism
- dementia
- cancer
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