Pathophysiology of Choline and Choline Transporters
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 10132
Special Issue Editor
Interests: molecular pharmacology; choline transporters; oncology; neuroscience
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Choline is an organic cation that is essential for the normal function of all cells. It is essential for the synthesis of membrane phospholipids, the methyl donor betaine, and the neurotransmitter acetylcholine. Choline is consumed in the diet and insufficient intake may cause choline deficiency, especially under conditions that require large amounts of choline, such as pregnancy, breast-feeding and parenteral nutrition. Choline deficiency affects the expression of genes involved in cell proliferation, differentiation, and apoptosis, and it is associated with liver dysfunction and cancer. Therefore, the study of choline transport and the characteristics of choline transporters are of central importance to understand the mechanisms that underlie membrane integrity and cell signaling. The choline transport system has been categorized into three transporter families. They include (I) polyspecific organic cation transporters (OCTs) with low affinity for choline, (II) high-affinity choline transporter 1 (CHT1), and (III) choline transporter-like proteins (CTLs). They are expressed in different organisms and cell types, and this implies its importance for choline transport for a broader purpose, such as acetylcholine and phospholipid synthesis.
This Special Issue focuses on the latest research on the pathophysiology of choline deficiency and its relationship to various diseases, and on the role of choline transporters in the pathophysiology and development of drugs as therapeutic targets. Authors are invited to submit original research and review papers addressing the topic of this Special Issue.
Prof. Dr. Masato Inazu
Guest Editor
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Keywords
- Choline deficiency
- Choline transporters
- Cancer
- Choline-PET
- Choline metabolism
- Dementia
- Acetylcholine
- Betaine
- Phospholipids
- Drug target
- Epigenetics
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