Gastrointestinal Hormones

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (20 June 2022) | Viewed by 4907

Special Issue Editor


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Guest Editor
Department of Pathology, Anatomy and Physiology, University of Navarra, Pamplona, Spain
Interests: cell biology; histology; adipose tissue; gut endocrinology; obesity

Special Issue Information

Dear Colleagues,

Well over 100 different peptides with hormonal activity are produced and released by specialized epithelial cells (enteroendocrine cells) as well as neurons distributed along the gastrointestinal tract. By different mechanisms, the expression of a single hormone gene can result in multiple peptides. Thus, several peptides belonging to the same or different families often coexist in these cells. Gastrointestinal hormones play an integral role in regulating the functions of the gastrointestinal tract. Besides their regulatory effects on secretion, absorption, digestion, and gut motility, they also have a fundamental role in gut–brain communication, particularly in the control of food intake and energy homeostasis. In this context, another important player has more recently emerged, the gut microbiota, whose interaction with gastrointestinal hormones seems to have a key role in better understanding the effects of diets and improving the treatment of some intestinal disorders.

The focus of this Special Issue of Biomolecules will be on the most recent advances in gastrointestinal hormones, which are an essential component in developing new therapies for metabolic diseases and intestinal disorders. We especially seek original research papers, but also welcome review articles presenting novelties or overviews that may contribute to a deeper insight into the mechanisms of gut hormone secretion and to the development of their therapeutic potential.

Dr. María Ángela Burrell Bustos
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastrointestinal hormones
  • enteroendocrine cells
  • appetite control
  • obesity
  • gut microbiota
  • metabolic diseases
  • intestinal disorders

Published Papers (1 paper)

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Review

19 pages, 797 KiB  
Review
Adrenomedullin: Not Just Another Gastrointestinal Peptide
by Sonia Martínez-Herrero and Alfredo Martínez
Biomolecules 2022, 12(2), 156; https://doi.org/10.3390/biom12020156 - 18 Jan 2022
Cited by 10 | Viewed by 4304
Abstract
Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are two bioactive peptides derived from the same precursor with several biological functions including vasodilation, angiogenesis, or anti-inflammation, among others. AM and PAMP are widely expressed throughout the gastrointestinal (GI) tract where they behave as [...] Read more.
Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are two bioactive peptides derived from the same precursor with several biological functions including vasodilation, angiogenesis, or anti-inflammation, among others. AM and PAMP are widely expressed throughout the gastrointestinal (GI) tract where they behave as GI hormones, regulating numerous physiological processes such as gastric emptying, gastric acid release, insulin secretion, bowel movements, or intestinal barrier function. Furthermore, it has been recently demonstrated that AM/PAMP have an impact on gut microbiome composition, inhibiting the growth of bacteria related with disease and increasing the number of beneficial bacteria such as Lactobacillus or Bifidobacterium. Due to their wide functions in the GI tract, AM and PAMP are involved in several digestive pathologies such as peptic ulcer, diabetes, colon cancer, or inflammatory bowel disease (IBD). AM is a key protective factor in IBD onset and development, as it regulates cytokine production in the intestinal mucosa, improves vascular and lymphatic regeneration and function and mucosal epithelial repair, and promotes a beneficial gut microbiome composition. AM and PAMP are relevant GI hormones that can be targeted to develop novel therapeutic agents for IBD, other GI disorders, or microbiome-related pathologies. Full article
(This article belongs to the Special Issue Gastrointestinal Hormones)
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