Glycine Transporters and Receptors as Targets for Analgesics
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (15 May 2021) | Viewed by 22981
Special Issue Editors
Interests: neurotransmitter transporters; drug discovery; protein structure and function;
Interests: neurotransmitter receptors; neurotransmitter transporters; autism; cognitive disorders; epilepsy; molecular and cellular biology
Special Issue Information
Dear Colleagues,
Professors Robert Harvey and Robert Vandenberg propose a themed issue for Biomolecules based on analysing the current information on the suitability of modulating glycinergic neurotransmission for the treatment of inflammatory and chronic pain. This area of research is gaining wider recognition as glycine receptors (GlyRs) and transporters (GlyT1 and GlyT2) are now considered potential therapeutic targets. This issue will explore a range of perspectives on this topic and we would like to include consideration of recent advances in: understanding the pathophysiology of glycine neurotransmission in pain states; structures and functions of transporters and receptors; mechanisms of transporter and receptor regulation; drug discovery programs; how potential drugs provide analgesia in animal models of pain; and the current state of clinical trials. We request that each author provide specific hypotheses about the key issues and how this field may be further developed. As part of this issue, Robert Vandenberg and Robert Harvey will provide an editorial highlighting the issues raised in the various articles and possible avenues for moving the field forward.
Prof. Dr. Robert Vandenberg
Prof. Dr. Robert Harvey
Guest Editors
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Keywords
- glycine
- transporter
- receptor
- analgesic
- pain
- drug discovery
- glycinergic neurotransmission
- clinical trials
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