Host-Microbiome Interactions in Health and Disease

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 3890

Special Issue Editor


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Guest Editor
Department of Biochemistry and Molecular Biology, University of Arkansas Medical Sciences, Little Rock, AR, USA
Interests: gut microbiome; chronic kidney disease; host–microbiome interactions; gut–brain axis; multi-omics; metaproteomics; data integration; network science; systems biology; mass spectrometry

Special Issue Information

Dear Colleagues,

In this Special Issue, we invite you to share your research in the field of microbiome–host interactions. The recent advent of large-scale post-genomics technologies now allows us to study these interactions at unprecedented resolution. We welcome studies focused on mechanisms of microbiome–host interactions in various contexts, for example: in cardiometabolic diseases; studies of gut–brain connection; the mechanism of action of microbiome-produced metabolites, such as short chain fatty acids; and investigations of the human gut microbiome as a therapeutic target with administration of pre-/pro-biotics. We also invite articles focused on the development of research methodologies, including innovative methods in metaproteomics, metagenomics, microbial metabolomics, bioinformatics analysis, and network and data integration. In addition, we welcome studies on microbiome–host co-evolution and the role that the gut microbiome plays in the domestication of agriculturally important species.

Dr. Boris L. Zybailov
Guest Editor

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Keywords

  • microbiome
  • cardiometabolic disease
  • gut–brain axis
  • network science
  • systems biology
  • omics data integration
  • metaproteomics
  • host–microbiome interactions
  • domestication

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Published Papers (1 paper)

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Research

13 pages, 1210 KiB  
Article
Fecal Metaproteomics Reveals Reduced Gut Inflammation and Changed Microbial Metabolism Following Lifestyle-Induced Weight Loss
by Ronald Biemann, Enrico Buß, Dirk Benndorf, Theresa Lehmann, Kay Schallert, Sebastian Püttker, Udo Reichl, Berend Isermann, Jochen G. Schneider, Gunter Saake and Robert Heyer
Biomolecules 2021, 11(5), 726; https://doi.org/10.3390/biom11050726 - 12 May 2021
Cited by 15 | Viewed by 3381
Abstract
Gut microbiota-mediated inflammation promotes obesity-associated low-grade inflammation, which represents a hallmark of metabolic syndrome. To investigate if lifestyle-induced weight loss (WL) may modulate the gut microbiome composition and its interaction with the host on a functional level, we analyzed the fecal metaproteome of [...] Read more.
Gut microbiota-mediated inflammation promotes obesity-associated low-grade inflammation, which represents a hallmark of metabolic syndrome. To investigate if lifestyle-induced weight loss (WL) may modulate the gut microbiome composition and its interaction with the host on a functional level, we analyzed the fecal metaproteome of 33 individuals with metabolic syndrome in a longitudinal study before and after lifestyle-induced WL in a well-defined cohort. The 6-month WL intervention resulted in reduced BMI (−13.7%), improved insulin sensitivity (HOMA-IR, −46.1%), and reduced levels of circulating hsCRP (−39.9%), indicating metabolic syndrome reversal. The metaprotein spectra revealed a decrease of human proteins associated with gut inflammation. Taxonomic analysis revealed only minor changes in the bacterial composition with an increase of the families Desulfovibrionaceae, Leptospiraceae, Syntrophomonadaceae, Thermotogaceae and Verrucomicrobiaceae. Yet we detected an increased abundance of microbial metaprotein spectra that suggest an enhanced hydrolysis of complex carbohydrates. Hence, lifestyle-induced WL was associated with reduced gut inflammation and functional changes of human and microbial enzymes for carbohydrate hydrolysis while the taxonomic composition of the gut microbiome remained almost stable. The metaproteomics workflow has proven to be a suitable method for monitoring inflammatory changes in the fecal metaproteome. Full article
(This article belongs to the Special Issue Host-Microbiome Interactions in Health and Disease)
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