Protein Degradation by the Ubiquitin-Proteasome Pathway in Health and Disease
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biomacromolecules: Proteins".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 7485
Special Issue Editor
Special Issue Information
Dear Colleagues,
Proper cellular function critically depends on the maintenance of a constant intracellular protein pool—an equilibrium which is determined by equal balance between protein synthesis and degradation. The breakdown of intracellular proteins in eukaryotic cells is ensured by two major machineries conserved from yeast to humans, namely, the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal system. The UPS allows for the specific elimination of ubiquitin-tagged proteins by the 26S proteasome in a process that involves more than 1000 genes. Although the UPS plays a crucial role in preserving protein homeostasis by targeting misfolded and/or damaged proteins for degradation, its function is not restricted to protein quality control. By mediating the ubiquitination/degradation of a wide range of mature proteins in response to specific stimuli, the UPS also regulates a myriad of processes such as gene expression, intracellular signaling, metabolism, cell proliferation and MHC class I antigen presentation, to name a few. The unique position of the UPS at the intersection of multiple pathways makes the cell particularly vulnerable to any defect in one of its components. Over the last couple of years, an increasing number of different types of neurological and immunological disorders have been associated with UPS dysfunction. Due to the extreme versatility of the UPS, our current understanding of their molecular pathogenesis remains obscure. Here, we welcome research articles and comprehensive reviews providing new insights into the molecular mechanisms by which protein breakdown by the UPS governs cell function in health and disease.
Dr. Frédéric Ebstein
Guest Editor
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Keywords
- ubiquitin-proteasome system
- proteostasis
- gene expression
- signal transduction
- cell proliferation and differentiation
- autoinflammation
- MHC class I antigen presentation
- neurodegeneration
- neurodevelopmental disorders
