Protein Misfolding in Neurodegenerative Diseases: Recent Advances and Therapeutical Implications
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (15 October 2021) | Viewed by 6578
Special Issue Editor
Interests: neurodegeneration; protein conformational disorders; alpha-synuclein; Parkinson's disease and related synucleinopathies; transthyretin (TTR); TTR-related amyloidosis
Special Issue Information
Dear Colleagues,
A common molecular hallmark feature shared by several clinicopathologically different neurodegenerative diseases is the altered protein homeostasis, leading to protein misfolding and the aggregation of a broad variety of otherwise soluble proteins in the form of insoluble amyloid deposits. Although the precise mechanisms by which protein misfolding and aggregation is involved in neurodegeneration are still unclear, compelling evidence supports a loss of physiological function and/or gain of toxic function upon protein misfolding, leading to the abnormal intra- or extracellular accumulation of amyloid deposits that are resistant to degradation playing a major role in the pathogenesis of protein conformational diseases. Building on these findings, several disease-modifying therapeutical approaches have been proposed, which target the different steps in the synthesis and processing of aggregation-prone proteins, including lowering the concentration of the amyloidogenic protein, stabilization of the protein native state conformation and therefore preventing its aggregation, modulation of the proteome quality control via proteasome and autophagy pathways, and decreasing the vicious cycle of amyloid formation seeding and spreading. The aim of this Special Issue is to summarise the current knowledge on the molecular mechanisms underlying protein misfolding and its relationship with neurotoxicity, and to highlight emerging therapeutic strategies for the prevention or treatment of neurodegenerative disorders associated with protein aggregation.
Dr. Nelson Ferreira
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
