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Biosensors
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Advances in Bioimaging and Biosensing
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Advances in Bioimaging and Biosensing

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 6567

Special Issue Editor

Prof. Dr. Qingtao Meng

E-Mail Website
Guest Editor
School of Chemical Engineering, University of Science and Technology Liaoning, Anshan 114051, China
Interests: fluorescence probe; biosensor; fluorescence imaging; diagnostic and therapeutic materials

Special Issue Information

Dear Colleagues,

Biomarkers play an important role in understanding the development of human diseases, and the identification of subgroups that are at increased risk of disease. The detection of biomarkers such as ions, active biomolecules, and vital enzymes in the physiological and pathological processes of living cells and in vivo has significance for the early diagnosis and treatment of diseases. Biosensing and bioimaging are becoming increasingly important techniques for disease diagnostics and management due to their non-invasiveness, near real-time feedback, real-time, high accuracy and reliability.

The aim of this Special Issue of Biosensors, “Advances in Bioimaging and Biosensing”, is to report recent developments and advances in molecular probes or nanoprobes for the detection and imaging of biomarkers in vivo or in vitro. This Special Issue is open to all researchers and welcomes papers relating to the proposed topic.

Prof. Dr. Qingtao Meng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fluorescence probe
  • chemosensor
  • biosensor
  • MRI probe
  • biomarker
  • detection
  • fluorescence imaging
  • dual-/multi-modal imaging
  • monitor treatment

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

10 pages, 1527 KiB  
Communication
Photoacoustic Chemical Imaging Sodium Nano-Sensor Utilizing a Solvatochromic Dye Transducer for In Vivo Application
by Jeff Folz, Jacalyn H. Wasserman, Janggun Jo, Xueding Wang and Raoul Kopelman
Biosensors 2023, 13(10), 923; https://doi.org/10.3390/bios13100923 - 11 Oct 2023
Viewed by 1684
Abstract
Sodium has many vital and diverse roles in the human body, including maintaining the cellular pH, generating action potential, and regulating osmotic pressure. In cancer, sodium dysregulation has been correlated with tumor growth, metastasis, and immune cell inhibition. However, most in vivo sodium [...] Read more.
Sodium has many vital and diverse roles in the human body, including maintaining the cellular pH, generating action potential, and regulating osmotic pressure. In cancer, sodium dysregulation has been correlated with tumor growth, metastasis, and immune cell inhibition. However, most in vivo sodium measurements are performed via Na23 NMR, which is handicapped by slow acquisition times, a low spatial resolution (in mm), and low signal-to-noise ratios. We present here a plasticizer-free, ionophore-based sodium-sensing nanoparticle that utilizes a solvatochromic dye transducer to circumvent the pH cross-sensitivity of most previously reported sodium nano-sensors. We demonstrate that this nano-sensor is non-toxic, boasts a 200 μM detection limit, and is over 1000 times more selective for sodium than potassium. Further, the in vitro photoacoustic calibration curve presented demonstrates the potential of this nano-sensor for performing the in vivo chemical imaging of sodium over the entire physiologically relevant concentration range. Full article
(This article belongs to the Special Issue Advances in Bioimaging and Biosensing)
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12 pages, 2052 KiB  
Article
Systematic Screening of Trigger Moieties for Designing Formaldehyde Fluorescent Probes and Application in Live Cell Imaging
by Yin Jiang, Shumei Huang, Minghui Liu, Zejun Li, Weimin Xiao, Huatang Zhang, Liu Yang and Hongyan Sun
Biosensors 2022, 12(10), 855; https://doi.org/10.3390/bios12100855 - 10 Oct 2022
Cited by 1 | Viewed by 1958
Abstract
Formaldehyde (FA) is involved in multiple physiological regulatory processes and plays a crucial role in memory storage. Meanwhile, FA has a notorious reputation as a toxic compound, and it will cause a variety of diseases if its level is unbalanced in the human [...] Read more.
Formaldehyde (FA) is involved in multiple physiological regulatory processes and plays a crucial role in memory storage. Meanwhile, FA has a notorious reputation as a toxic compound, and it will cause a variety of diseases if its level is unbalanced in the human body. To date, there have been numerous fluorescent probes for FA imaging reported. Among them, the probes based on the 2−aza−Cope rearrangement have attracted the most attention, and their applications in cell imaging have been greatly expanded. Herein, we screened the various trigger moieties of FA fluorescent probes based on the mechanism of 2−aza−Cope rearrangement. FA−2, in which a fluorophore is connected to a 4−nitrobenzylamine group and an allyl group, demonstrated the highest sensitivity, selectivity, and reaction kinetics. Furthermore, FA−Lyso, derived from FA−2, has been successfully designed and applied to monitor exogenous and endogenous FA fluctuations in lysosomes of living cells. Full article
(This article belongs to the Special Issue Advances in Bioimaging and Biosensing)
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9 pages, 1859 KiB  
Communication
An Ultrasensitive Picric Acid Sensor Based on a Robust 3D Hydrogen-Bonded Organic Framework
by Weiwei Jiang, Lingling Xia, Dan Li, Pengyan Wu, Tongtong Zou, Xingcheng Yuan, Wen Wei and Jian Wang
Biosensors 2022, 12(9), 682; https://doi.org/10.3390/bios12090682 - 25 Aug 2022
Cited by 9 | Viewed by 2293
Abstract
Hydrogen-bonded organic frameworks (HOFs), as a newly developed porous material, have been widely used in various fields. To date, several organic building units (OBUs) with tri-, tetra-, and hexa-carboxylic acid synthons have been applied to synthesize HOFs. To our knowledge, di-carboxylic acids have [...] Read more.
Hydrogen-bonded organic frameworks (HOFs), as a newly developed porous material, have been widely used in various fields. To date, several organic building units (OBUs) with tri-, tetra-, and hexa-carboxylic acid synthons have been applied to synthesize HOFs. To our knowledge, di-carboxylic acids have rarely been reported for the construction of HOFs, in particular, di-carboxylic acid-based HOFs with fluorescence sensing properties have not been reported. In this study, a rare example of a di-carboxylic acid-based, luminescent three-dimensional hydrogen-bonded organic framework has been successfully constructed and structurally characterized; it has a strong electron-rich property originated from its organic linker 9-phenylcarbazole-3,6-dicarboxylic acid. It represents the first example of HOF-based sensors for the highly selective and sensitive detection of PA (Picric acid) with reusability; the LOD is less than 60 nM. This work thus provides a new avenue for the fabrication of fluorescent HOFs sensing towards explosives. Full article
(This article belongs to the Special Issue Advances in Bioimaging and Biosensing)
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