Advances in Nanopore Biosensors
A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 789
Special Issue Editors
Interests: nanopore; biosensors; protein-protein interaction
Interests: biosensors; chemosensors; organo-functional materials; CRISPR; optical sensors
Interests: biosensing devices for infectious and non-infectious disease diagnoses; nanopore sensing technologies; point-of-care testing; real-time sensing technologies for microfluidic organs on chips
Special Issue Information
Dear Colleagues,
Nanopore sensing technologies have gained tremendous popularity in recent years for diagnostic applications due to their label-free single-molecule detection capabilities. The emerging applications include detection of disease biomarkers like RNA, DNA, proteins, and peptides with high sensitivity and specificity; DNA and protein sequencing; detection of environmental pollutants and food contaminants like heavy metals, microplastics, food pathogens, etc. The nanopore detection mechanism is based on resistive pulse sensing in the ionic current established between two salt-solution reservoirs, separated by either a biological or a solid-state nanopore when a molecule passes through it under the influence of an applied electric field. While the biological nanopores are being widely explored for sequencing applications, the innovations in solid-state nanopores are leading the way for rapid and early diagnosis of infectious and non-infectious diseases. The use of various types of nanopore configurations, nanomaterial-based surface modifications, and the use of inorganic, organic, and hybrid materials have contributed to the improvement in the sensing performance of nanopore biosensors. However, variations in nanopore diameters, low signal-to-noise-ratios, and physical properties of these nanopore biosensors greatly impact the molecular transport dynamics. Therefore, there is still a critical need for highly reproducible, stable, and sensitive nanopore systems for expanding their application portfolio as a clinical tool in biomedical fields.
For this Special Issue, we welcome original research papers as well as reviews on the recent advancements in the development of highly sensitive and specific biological and solid-state nanopore biosensing technologies. This includes the design and fabrication of state-of-the-art nanopore biosensors for disease biomarkers, characterization of biomolecules like secretions from single cells, study of nanopore transport mechanisms, and point-of-care implementations. To expand on the contributions to this Special Issue, the original theoretical research on multiparametric modelling of the molecular transport through different nanopores is also encouraged. The design and development of nanopore-based point-of-care diagnostic systems is of special interest. Reviews should provide an in-depth examination of the most recent research in a specific context or discuss the existing and future issues related to nanopore sensing in the biomedical field.
Dr. Ki-baek Jeong
Dr. Sathishkumar Munusamy
Dr. Muhammad Asad Ullah Khalid
Guest Editors
Manuscript Submission Information
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Keywords
- nanopore
- biosensor
- single-molecule detection
- biological nanopore
- solid-state nanopore
- disease diagnosis
- DNA detection
- protein detection
- point-of-care nanopore
- nanomaterial
- functionalized nanopore
- sequencing
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