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Biosensors
Special Issues
Electrochemical Biosensors: From Design to Applications
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Electrochemical Biosensors: From Design to Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 13092

Special Issue Editors

Dr. Young-Joon Kim

E-Mail Website
Guest Editor
Department of Electronic Engineering, Gachon University, Seongnam 13120, Republic of Korea
Interests: continuous physiological signal monitoring; biosensors; wireless power transfer
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Sungbo Cho

E-Mail Website
Guest Editor
Department of Electronic Engineering, Gachon University, Seongnam 13120, Gyeonggi-Do, Republic of Korea
Interests: electrochemical biosensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The electrochemical biosensor is a type of sensor that transduces biochemical events such as enzyme-substrate reaction and antigen-antibody interaction to electrical signals. Over the years, various types of electrochemical biosensors have been introduced and commercialized for diverse applications, due to their accuracy, cost-effectiveness, and sensitivity. Owing to the fact that these biosensors yield an electrical signal, a miniaturized measurement and diagnosis method is achievable based on electronic systems, suitable for portable, wearable, or implantable applications. Therefore, this Special Issue on “Electrochemical Biosensors: From Design to Applications” focuses on recent advances in the development of electrochemical biosensors and their feasibility for various applications.

We invite submissions of research that help to advance the field of electrochemical biosensor technology and its application for easy diagnosis and status monitoring that can further promote at-home medical service. 

Dr. Young-Joon Kim
Dr. Sungbo Cho
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (3 papers)

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Research

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13 pages, 1775 KiB  
Article
Catalytic Modification of Porous Two-Dimensional Ni-MOFs on Portable Electrochemical Paper-Based Sensors for Glucose and Hydrogen Peroxide Detection
by Ya Yang, Wenhui Ji, Yutao Yin, Nanxiang Wang, Wanxia Wu, Wei Zhang, Siying Pei, Tianwei Liu, Chao Tao, Bing Zheng, Qiong Wu and Lin Li
Biosensors 2023, 13(5), 508; https://doi.org/10.3390/bios13050508 - 28 Apr 2023
Cited by 16 | Viewed by 3132
Abstract
Rapid and accurate detection of changes in glucose (Glu) and hydrogen peroxide (H2O2) concentrations is essential for the predictive diagnosis of diseases. Electrochemical biosensors exhibiting high sensitivity, reliable selectivity, and rapid response provide an advantageous and promising solution. A [...] Read more.
Rapid and accurate detection of changes in glucose (Glu) and hydrogen peroxide (H2O2) concentrations is essential for the predictive diagnosis of diseases. Electrochemical biosensors exhibiting high sensitivity, reliable selectivity, and rapid response provide an advantageous and promising solution. A porous two-dimensional conductive metal–organic framework (cMOF), Ni-HHTP (HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene), was prepared by using a one-pot method. Subsequently, it was employed to construct enzyme-free paper-based electrochemical sensors by applying mass-producing screen-printing and inkjet-printing techniques. These sensors effectively determined Glu and H2O2 concentrations, achieving low limits of detection of 1.30 μM and 2.13 μM, and high sensitivities of 5573.21 μA μM−1 cm−2 and 179.85 μA μM−1 cm−2, respectively. More importantly, the Ni-HHTP-based electrochemical sensors showed an ability to analyze real biological samples by successfully distinguishing human serum from artificial sweat samples. This work provides a new perspective for the use of cMOFs in the field of enzyme-free electrochemical sensing, highlighting their potential for future applications in the design and development of new multifunctional and high-performance flexible electronic sensors. Full article
(This article belongs to the Special Issue Electrochemical Biosensors: From Design to Applications)
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18 pages, 11325 KiB  
Article
An Amperometric Acetylcholine Biosensor Based on Co-Immobilization of Enzyme Nanoparticles onto Nanocomposite
by Jyoti Ahlawat, Minakshi Sharma and Chandra Shekhar Pundir
Biosensors 2023, 13(3), 386; https://doi.org/10.3390/bios13030386 - 15 Mar 2023
Cited by 9 | Viewed by 2609
Abstract
An electrochemical biosensor was fabricated using nanoparticles of acetylcholinesterase (AChE) and choline oxidase (ChO)/Pt nanoparticles (PtNPs)/porous graphene oxide nanosheet (GONS) composite. A pencil graphite electrode (PGE) was used for the electrodeposition of nanocomposite and the determination of acetylcholine (ACh), a neurotransmitter. Various techniques [...] Read more.
An electrochemical biosensor was fabricated using nanoparticles of acetylcholinesterase (AChE) and choline oxidase (ChO)/Pt nanoparticles (PtNPs)/porous graphene oxide nanosheet (GONS) composite. A pencil graphite electrode (PGE) was used for the electrodeposition of nanocomposite and the determination of acetylcholine (ACh), a neurotransmitter. Various techniques such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectra and cyclic voltammetry (CV) were used for characterization. This biosensor (AChENPs-ChONPs/GONS/PtNPs/PGE) indicated a very short response time (3 s), a lower limit of detection (0.001 µM), good linearity (0.001–200 µM), longer storage stability (6 months) and better reproducibility. The percent analytical recoveries of added acetylcholine in serum (5.0 and 10 µM) were found to be 97.6 ± 0.7 and 96.5 ± 0.3 for the present biosensor. The coefficients of variation were obtained to be 8% and 3.25%, correspondingly. The biosensor was applied to measure the ACh amount in the serum of healthy individuals and patients with Alzheimer’s disease. The number of interferents had no effect on the biosensor at their physiological concentrations. Full article
(This article belongs to the Special Issue Electrochemical Biosensors: From Design to Applications)
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Review

Jump to: Research

36 pages, 4712 KiB  
Review
Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules
by K. Theyagarajan and Young-Joon Kim
Biosensors 2023, 13(4), 424; https://doi.org/10.3390/bios13040424 - 27 Mar 2023
Cited by 32 | Viewed by 6588
Abstract
Electrochemical biosensors are superior technologies that are used to detect or sense biologically and environmentally significant analytes in a laboratory environment, or even in the form of portable handheld or wearable electronics. Recently, imprinted and implantable biosensors are emerging as point-of-care devices, which [...] Read more.
Electrochemical biosensors are superior technologies that are used to detect or sense biologically and environmentally significant analytes in a laboratory environment, or even in the form of portable handheld or wearable electronics. Recently, imprinted and implantable biosensors are emerging as point-of-care devices, which monitor the target analytes in a continuous environment and alert the intended users to anomalies. The stability and performance of the developed biosensor depend on the nature and properties of the electrode material or the platform on which the biosensor is constructed. Therefore, the biosensor platform plays an integral role in the effectiveness of the developed biosensor. Enormous effort has been dedicated to the rational design of the electrode material and to fabrication strategies for improving the performance of developed biosensors. Every year, in the search for multifarious electrode materials, thousands of new biosensor platforms are reported. Moreover, in order to construct an effectual biosensor, the researcher should familiarize themself with the sensible strategies behind electrode fabrication. Thus, we intend to shed light on various strategies and methodologies utilized in the design and fabrication of electrochemical biosensors that facilitate sensitive and selective detection of significant analytes. Furthermore, this review highlights the advantages of various electrode materials and the correlation between immobilized biomolecules and modified surfaces. Full article
(This article belongs to the Special Issue Electrochemical Biosensors: From Design to Applications)
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