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Biosensors
Special Issues
Advanced Electrochemical Biosensors and Their Applications
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Advanced Electrochemical Biosensors and Their Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 892

Special Issue Editors

Dr. Matias Regiart

E-Mail Website
Guest Editor
Instituto de Química de San Luis (INQUISAL), Facultad de Química, Bioquímica y Farmacia (FQBF), Universidad Nacional de San Luis (UNSL), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), INQUISAL (UNSL—CONICET), Chacabuco 917, San Luis D5700BWS, Argentina
Interests: electrochemicals; sensors; analytical chemistry; nanotechnology; nanomaterials; biosensors; microfluidics
Prof. Dr. Walter Ricardo Brito

E-Mail Website
Guest Editor
Department of Chemistry, Federal University of Amazonas, Manaus 69067-005, AM, Brazil
Interests: electrochemicals; sensors; analytical chemistry; nanotechnology; nanomaterials; biosensors; microfluidics
Special Issues, Collections and Topics in MDPI journals
Dr. Martín A. Fernández-Baldo

E-Mail Website
Guest Editor
Instituto de Química de San Luis (INQUISAL), Facultad de Química, Bioquímica y Farmacia (FQBF), Universidad Nacional de San Luis (UNSL), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), INQUISAL (UNSL— CONICET), Chacabuco 917, San Luis D5700BWS, Argentina.
Interests: electrochemicals; sensors; analytical chemistry; nanotechnology; nanomaterials; biosensors; microfluidics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to present this Special Issue, "Advanced Electrochemical Biosensors and their Applications", which aims to highlight the most recent advances and technological breakthroughs in the field of electrochemical biosensors. As the demand for highly sensitive, portable, and cost-effective biosensors continues to grow, especially in areas such as medical diagnostics, environmental monitoring, and food safety, electrochemical biosensors have emerged as one of the most promising and versatile technologies. This Special Issue focuses on bringing together cutting-edge research and developments that address both the scientific and engineering challenges in electrochemical biosensing. Topics of interest include, but are not limited to, the following:

  • Nanomaterial-enhanced biosensors that leverage the unique properties of materials like graphene, carbon nanotubes, and metal nanoparticles to improve sensor performance.
  • Wearable and flexible biosensors designed for the real-time monitoring of physiological parameters.
  • Point-of-care (POC) diagnostics, emphasizing miniaturization, portability, and integration with mobile technologies for easy and rapid detection.
  • Aptasensors and immunosensors for the highly specific detection of biomarkers, pathogens, and environmental pollutants.
  • Machine learning integration in biosensor data analysis, helping to refine sensitivity and address challenges such as noise reduction in complex sample matrices.

We invite contributions that explore novel fabrication techniques, innovative applications, and real-world case studies where electrochemical biosensors are making significant impacts. Our goal with this issue is to create a platform for the dissemination of breakthrough research and facilitate collaborations between scientists and engineers in various fields.

We are confident that the contributions to this Special Issue will inspire further research and foster new innovations in the field of electrochemical biosensors. We look forward to receiving your submissions and sharing this exciting work with the scientific community.

Dr. Matias Regiart
Prof. Dr. Walter Ricardo Brito
Dr. Martín A. Fernández-Baldo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrochemical
  • nanotechnology
  • sensors
  • microfluidics
  • biosensing
  • nanomaterials
  • biosensors

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Published Papers (1 paper)

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Research

18 pages, 6409 KiB  
Communication
A Highly Stable Electrochemical Sensor Based on a Metal–Organic Framework/Reduced Graphene Oxide Composite for Monitoring the Ammonium in Sweat
by Yunzhi Hua, Junhao Mai, Rourou Su, Chengwei Ma, Jiayi Liu, Cong Zhao, Qian Zhang, Changrui Liao and Yiping Wang
Biosensors 2024, 14(12), 617; https://doi.org/10.3390/bios14120617 - 15 Dec 2024
Viewed by 649
Abstract
The demand for non-invasive, real-time health monitoring has driven advancements in wearable sensors for tracking biomarkers in sweat. Ammonium ions (NH4+) in sweat serve as indicators of metabolic function, muscle fatigue, and kidney health. Although current ion-selective all-solid-state printed sensors [...] Read more.
The demand for non-invasive, real-time health monitoring has driven advancements in wearable sensors for tracking biomarkers in sweat. Ammonium ions (NH4+) in sweat serve as indicators of metabolic function, muscle fatigue, and kidney health. Although current ion-selective all-solid-state printed sensors based on nanocomposites typically exhibit good sensitivity (~50 mV/log [NH4+]), low detection limits (LOD ranging from 10−6 to 10−7 M), and wide linearity ranges (from 10−5 to 10−1 M), few have reported the stability test results necessary for their integration into commercial products for future practical applications. This study presents a highly stable, wearable electrochemical sensor based on a composite of metal–organic frameworks (MOFs) and reduced graphene oxide (rGO) for monitoring NH4+ in sweat. The synergistic properties of Ni-based MOFs and rGO enhance the sensor’s electrochemical performance by improving charge transfer rates and expanding the electroactive surface area. The MOF/rGO sensor demonstrates high sensitivity, with a Nernstian response of 59.2 ± 1.5 mV/log [NH4+], an LOD of 10−6.37 M, and a linearity range of 10−6 to 10−1 M. Additionally, the hydrophobic nature of the MOF/rGO composite prevents water layer formation at the sensing interface, thereby enhancing long-term stability, while its high double-layer capacitance minimizes potential drift (7.2 µV/s (i = ±1 nA)) in short-term measurements. Extensive testing verified the sensor’s exceptional stability, maintaining consistent performance and stable responses across varying NH4+ concentrations over 7 days under ambient conditions. On-body tests further confirmed the sensor’s suitability for the continuous monitoring of NH4+ levels during physical activities. Further investigations are required to fully elucidate the impact of interference from other sweat components (such as K+, Na+, Ca2+, etc.) and the influence of environmental factors (including the subject’s physical activity, posture, etc.). With a clearer understanding of these factors, the sensor has the potential to emerge as a promising tool for wearable health monitoring applications. Full article
(This article belongs to the Special Issue Advanced Electrochemical Biosensors and Their Applications)
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