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Biosensors
Special Issues
Microfluidic Chip for In Vitro Diagnostic Assays
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Microfluidic Chip for In Vitro Diagnostic Assays

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 3709

Special Issue Editors

Dr. Peng Chen

E-Mail Website
Guest Editor
Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Interests: microfluidics; POCT; IVD (In Vitro Diagnostic); Exosomes
Prof. Dr. Yiwei Li

E-Mail Website
Guest Editor
Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Interests: microfluidics; POCT; organoid

Special Issue Information

Dear Colleagues,

The main topic of this Special Issue concerns the application of new principles, new methods, and new technologies of microfluidics in the field of in vitro diagnostic assays. For that, this Special Issue seeks to publish original articles and reviews on novel microfluidic fabrication; sampling and detection technologies and methods; and their applications in biochemical assays, immunoassays, molecular diagnostics, and microbial and cellular assays. You are invited to participate in this project. Any contribution in this sense is welcome to this Special Issue.

If you are interested in submitting a contribution, or if you have any questions, please do not hesitate to contact me.

Dr. Peng Chen
Prof. Dr. Yiwei Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidic
  • chips
  • POCT (point-of-care testing)
  • IVD (In Vitro Diagnostic)
  • lab on a chip
  • biochemical assays
  • immunoassays
  • molecular diagnostics

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Published Papers (1 paper)

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Research

15 pages, 3449 KiB  
Communication
Design, Simulation, and Evaluation of Polymer-Based Microfluidic Devices via Computational Fluid Dynamics and Cell Culture “On-Chip”
by Nurzhanna Bakuova, Sultanali Toktarkan, Darkhan Dyussembinov, Dulat Azhibek, Almas Rakhymzhanov, Konstantinos Kostas and Gulsim Kulsharova
Biosensors 2023, 13(7), 754; https://doi.org/10.3390/bios13070754 - 22 Jul 2023
Cited by 7 | Viewed by 3201
Abstract
Organ-on-a-chip (OoC) technology has experienced exponential growth driven by the need for a better understanding of in-organ processes and the development of novel approaches. This paper investigates and compares the flow behavior and filling characteristics of two microfluidic liver-on-a-chip devices using Computational Fluid [...] Read more.
Organ-on-a-chip (OoC) technology has experienced exponential growth driven by the need for a better understanding of in-organ processes and the development of novel approaches. This paper investigates and compares the flow behavior and filling characteristics of two microfluidic liver-on-a-chip devices using Computational Fluid Dynamics (CFD) analysis and experimental cell culture growth based on the Huh7 cell line. The conducted computational analyses for the two chips showed that the elliptical chamber chip proposed herein offers improved flow and filling characteristics in comparison with the previously presented circular chamber chip. Huh7 hepatoma cells were cultured in the microfluidic devices for 24 h under static fluidic conditions and for 24 h with a flow rate of 3 μL·min−1. Biocompatibility, continuous flow, and biomarker studies showed cell attachment in the chips, confirming the cell viability and their consistent cell growth. The study successfully analyzed the fluid flow behavior, filling characteristics, and biocompatibility of liver-on-a-chip prototype devices, providing valuable insights to improve design and performance and advance alternative methods of in vitro testing. Full article
(This article belongs to the Special Issue Microfluidic Chip for In Vitro Diagnostic Assays)
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