Surface-Enhanced Raman Scattering Biosensors (Volume II)

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: 30 January 2025 | Viewed by 1529

Special Issue Editor


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Guest Editor
National Institute for Research and Development of Isotopic and Molecular Technologies, 400293 Cluj Napoca, Romania
Interests: SERS; biosensing; miniaturized devices; PoC devices; clinical applications of SERS; spectral pathology; liquid SERS-based biopsy; SERS based diagnosis; SERS on bacteria
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Special Issue Information

Dear Colleagues,

Like every up-to-date analytical technique with high potential for clinical application, surface-enhanced Raman scattering (SERS) spectroscopy has evolved into a futuristic asset in point-of-care (PoC) analysis. SERS-based biosensing approaches offer promising solutions for the identification of pathogens, rapid testing for viruses, glucose or O2 saturation, antibiotic susceptibility testing, early cancer diagnosis or prognosis, and various other crucial clinical issues. With this Special Issue, we intend to comprehensively collect relevant SERS biosensors studies with potential in PoC testing and off-site use, with a view to improving healthcare accessibility and sustainability.

In this Special Issue, we will also provide the latest input resulting from synergistic approaches like SERS and machine learning, SERS-based spectral pathology enhanced via chemometrics and adaptive, robust computational tools, or SERS-based setups that integrate digital technology for ultrasensitivity and reliability.

Topics of interest to this Special Issue include, but are not limited to, the following:

  • Label-free and label-based SERS bioassays;
  • Miniaturized SERS-activated platforms for biosensing;
  • Data augmentation in spectral pathology and diagnosis;
  • Modern and conventional chemometric tools for high-accuracy SERS data analysis;
  • Single-cell SERS detection of morphological variations associated with chronic diseases;
  • Microfluidic SERS-based devices for clinical use;
  • Functional, original SERS-based setups for diagnosis and malignancy monitoring;
  • Nanomaterials’ interaction with viable cells for susceptibility testing, drug delivery and efficient treatment.

Dr. Nicoleta Elena Dina
Guest Editor

Manuscript Submission Information

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Keywords

  • SERS
  • biosensing
  • miniaturized devices
  • PoC devices
  • clinical applications of SERS
  • SERS-based diagnosis

Published Papers (1 paper)

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Research

21 pages, 14303 KiB  
Article
Pilot SERS Monitoring Study of Two Natural Hypersaline Lake Waters from a Balneary Resort during Winter-Months Period
by Csilla Molnár, Teodora Diana Drigla, Lucian Barbu-Tudoran, Ilirjana Bajama, Victor Curean and Simona Cîntă Pînzaru
Biosensors 2024, 14(1), 19; https://doi.org/10.3390/bios14010019 - 29 Dec 2023
Viewed by 1285
Abstract
Water samples from two naturally hypersaline lakes, renowned for their balneotherapeutic properties, were investigated through a pilot SERS monitoring program. Nanotechnology-based techniques were employed to periodically measure the ultra-sensitive SERS molecular characteristics of the raw water-bearing microbial community and the inorganic content. Employing [...] Read more.
Water samples from two naturally hypersaline lakes, renowned for their balneotherapeutic properties, were investigated through a pilot SERS monitoring program. Nanotechnology-based techniques were employed to periodically measure the ultra-sensitive SERS molecular characteristics of the raw water-bearing microbial community and the inorganic content. Employing the Pearson correlation coefficient revealed a robust linear relationship between electrical conductivity and pH and Raman and SERS spectral data of water samples, highlighting the interplay complexity of Raman/SERS signals and physicochemical parameters within each lake. The SERS data obtained from raw waters with AgNPs exhibited a dominant, reproducible SERS feature resembling adsorbed β-carotene at submicromole concentration, which could be related to the cyanobacteria-AgNPs interface and supported by TEM analyses. Notably, spurious SERS sampling cases showed molecular traces attributed to additional metabolites, suggesting multiplexed SERS signatures. The conducted PCA demonstrated observable differences in the β-carotene SERS band intensities between the two lakes, signifying potential variations in picoplankton abundance and composition or environmental influences. Moreover, the study examined variations in the SERS intensity ratio I245/I1512, related to the balance between inorganic (Cl-induced AgNPs aggregation) and organic (cyanobacteria population) balance, in correlation with the electrical conductivity. These findings signify the potential of SERS data for monitoring variations in microorganism concentration, clearly dependent on ion concentration and nutrient dynamics in raw, hypersaline water bodies. Full article
(This article belongs to the Special Issue Surface-Enhanced Raman Scattering Biosensors (Volume II))
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