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Biosensors
Special Issues
Polymer-Dot-Based Biosensors for Biomedical Applications
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Polymer-Dot-Based Biosensors for Biomedical Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 3000

Special Issue Editor

Dr. Kai Sun

E-Mail Website
Guest Editor
School of Bioengineering, Dalian University of Technology, Dalian 116023, China
Interests: biomedical photonics; biosensing; optical diagnosis and therapy; fluorescent imaging

Special Issue Information

Dear Colleagues,

Nano-fluorescence technology is playing an increasingly important role in modern biomedical research and shows great potential for applications in the detection, diagnosis and treatment of health and major diseases. Among them, semiconducting polymer nanoparticles, also known as polymer dots (Pdots) are a new type of organic optical nanomaterials that has been subject to in-depth research by researchers at home and abroad in recent years. Compared with traditional luminescent materials, polymer nanoparticles are particularly suitable for their outstanding characteristics, including extraordinary fluorescence brightness, fast emission rate, excellent photostability, and nonblinking and nontoxic features. Pdots have demonstrated utility in a wide range of applications such as fluorescence imaging and biosensing, such as cellular labeling, in vivo imaging, single-particle tracking, biosensing, and drug delivery. Pdot technology is expected to have a broad and lasting impact on biomedical imaging, diagnosis and therapy.

Dr. Kai Sun
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer dots
  • biosensor
  • diagnosis
  • therapy
  • imaging

Published Papers (1 paper)

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Research

14 pages, 3575 KiB  
Article
Fabrication of P and N Co-Doped Carbon Dots for Fe3+ Detection in Serum and Lysosomal Tracking in Living Cells
by Yanzhi Xing, Mei Yang and Xuwei Chen
Biosensors 2023, 13(2), 230; https://doi.org/10.3390/bios13020230 - 5 Feb 2023
Cited by 7 | Viewed by 2546
Abstract
Doping with heteroatoms allows the retention of the general characteristics of carbon dots while allowing their physicochemical and photochemical properties to be effectively modulated. In this work, we report the preparation of ultrastable P and N co-doped carbon dots (PNCDs) that can be [...] Read more.
Doping with heteroatoms allows the retention of the general characteristics of carbon dots while allowing their physicochemical and photochemical properties to be effectively modulated. In this work, we report the preparation of ultrastable P and N co-doped carbon dots (PNCDs) that can be used for the highly selective detection of Fe3+ and the tracking of lysosomes in living cells. Fluorescent PNCDs were facilely prepared via a hydrothermal treatment of ethylenediamine and phytic acid, and they exhibited a high quantum yield of 22.0%. The strong coordination interaction between the phosphorus groups of PNCDs and Fe3+ rendered them efficient probes for use in selective Fe3+ detection, with a detection limit of 0.39 μM, and we demonstrated their practicability by accurately detecting the Fe3+ contents in bio-samples. At the same time, PNCDs exhibited high lysosomal location specificity in different cell lines due to surface lipophilic amino groups, and real-time tracking of the lysosome morphology in HeLa cells was achieved. The present work suggests that the fabrication of heteroatom-doped CDs might be an effective strategy to provide promising tools for cytology, such as organelle tracking. Full article
(This article belongs to the Special Issue Polymer-Dot-Based Biosensors for Biomedical Applications)
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