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Biosensors
Special Issues
Trend in Optical Sensors for Medical Diagnostics and Therapeutics
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Trend in Optical Sensors for Medical Diagnostics and Therapeutics

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Optical and Photonic Biosensors".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 14406

Special Issue Editors

Dr. Atul Sharma

E-Mail Website
Guest Editor
Department of Pharmaceutical Chemistry, SGT College of Pharmacy, SGT University, Gurugram, India
Interests: optical biosensor; biomarkers monitoring; surface plasmon resonance; nanomaterials/nanoparticles; bioanalytical techniques
Prof. Dr. Hui Ma

E-Mail Website
Guest Editor
Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
Interests: microscopic imaging and microfluorescence analysis
Dr. Swapnil Tiwari

E-Mail Website
Guest Editor
School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur 492010, Chattisgarh, India
Interests: optical biosensor; biomarkers monitoring; surface plasmon resonance; nanomaterials/nanoparticles; bioanalytical techniques

Special Issue Information

Dear Colleagues,

Over the last two decades, optical biosensors have been investigated for their ability in healthcare biosensing. Thus, their application in medical diagnostics and therapies is a rapidly expanding field. Specifically, label-free optical biosensors have become particularly appealing options due to a number of unique characteristics, such as their use of light and excellent bioanalytical performance. Their application is gaining traction in multiple fields, including healthcare, point-of-care testing devices, and biomarker monitoring.

This Special Issue on "Trends in Optical Sensors for Medical Diagnostics and Therapeutics" aims to bring together novel biosensing and bio-analytical technologies, as well as optical detection approaches for medical diagnostic and therapeutic purposes. We also invite researchers to show how unique optical biosensor applications in healthcare and real-time biomarker monitoring might help with treatment alternatives. Surface plasmon resonance, luminescence, nanoparticles, FT-IR, fibers, photonic crystals, and different free-form optics, when combined with chemical surface functionalization processes and/or biological recognition elements, enable the construction of numerous forms of optical biosensors. These conjugated sensing platforms make it easier to take advantage of their esoteric synergistic properties in sensor construction. In addition, portable lab-on-a-chip systems that use optical detection principles enable the quick, real-time monitoring of human health during daily activities.

We encourage you to submit research articles and reviews to this Special Issue to share your work, knowledge, insights, and recent accomplishments with the biosensor research community.

Dr. Atul Sharma
Prof. Dr. Hui Ma
Dr. Swapnil Tiwari
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical biosensor
  • biomarkers monitoring
  • surface plasmon resonance
  • nanomaterials/nanoparticles
  • bioanalytical techniques
  • therapeutics
  • photonic crystals
  • optics
  • chemiluminescence
  • aptamers/antibodies
  • bio-recognition elements
  • FT-IR
  • health monitoring
  • theranostics

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Published Papers (5 papers)

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Research

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11 pages, 2625 KiB  
Article
Detection of Advanced Glycosylation End Products in the Cornea Based on Molecular Fluorescence and Machine Learning
by Jianming Zhu, Sifeng Lian, Haochen Zhong, Ruiyang Sun, Zhenbang Xiao and Hua Li
Biosensors 2023, 13(2), 170; https://doi.org/10.3390/bios13020170 - 21 Jan 2023
Cited by 2 | Viewed by 1831
Abstract
Advanced glycosylation end products (AGEs) are continuously produced and accumulated in the bodies of diabetic patients. To effectively predict disease trends in diabetic patients, a corneal fluorescence detection device was designed based on the autofluorescence properties of AGEs, and corneal fluorescence measurements were [...] Read more.
Advanced glycosylation end products (AGEs) are continuously produced and accumulated in the bodies of diabetic patients. To effectively predict disease trends in diabetic patients, a corneal fluorescence detection device was designed based on the autofluorescence properties of AGEs, and corneal fluorescence measurements were performed on 83 volunteers. Multiple linear regression (MLR), extreme gradient boosting (XGBoost), support vector regression (SVR), and back-propagation neural network (BPNN) were used to predict the human AGE content. Physiological parameters which may affect corneal AGE content were collected for a correlation analysis to select the features that had a strong correlation with the corneal concentration of AGEs to participate in modeling. By comparing the predictive effects of the four models in the two cases of a single-input feature and a multi-input feature, it was found that the model with the single-input feature had a better predictive effect. In this case, corneal AGE content was predicted by a single-input SVR model, with the average error rate (AER), mean square error (MSE), and determination coefficient R-squared (R2) of the SVR model calculated as 2.43%, 0.026, and 0.932, respectively. These results proved the potential of our method and device for noninvasive detection of the concentration of AGEs in the cornea. Full article
(This article belongs to the Special Issue Trend in Optical Sensors for Medical Diagnostics and Therapeutics)
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19 pages, 3049 KiB  
Article
Design and Engineering of a Palm-Sized Optical Immunosensing Device for the Detection of a Kidney Dysfunction Biomarker
by Divya, Supratim Mahapatra and Pranjal Chandra
Biosensors 2022, 12(12), 1118; https://doi.org/10.3390/bios12121118 - 2 Dec 2022
Cited by 7 | Viewed by 2724
Abstract
Creatinine is one of the most common and specific biomarkers for renal diseases, usually found in the serum and urine of humans. Its level is extremely important and critical to know, not only in the case of renal diseases, but also for various [...] Read more.
Creatinine is one of the most common and specific biomarkers for renal diseases, usually found in the serum and urine of humans. Its level is extremely important and critical to know, not only in the case of renal diseases, but also for various other pathological conditions. Hence, detecting creatinine in clinically relevant ranges in a simplistic and personalized manner is interesting and important. In this direction, an optical sensing device has been developed for the simple, point-of-care detection of creatinine. The developed biosensor was able to detect creatinine quantitatively based on optical signals measured through a change in color. The sensor has been integrated with a smartphone to develop a palm-sized device for creatinine analysis in personalized settings. The sensor has been developed following facile chemical modification steps to anchor the creatinine-selective antibody to generate a sensing probe. The fabricated sensor has been thoroughly characterized by FTIR, AFM, and controlled optical analyses. The quantitative analysis is mediated through the reaction between picric acid and creatinine which was detected by the antibody-functionalized sensor probe. The differences in color intensity and creatinine concentrations show an excellent dose-dependent correlation in two different dynamic ranges from 5 to 20 μM and 35 to 400 μM, with a detection limit of 15.37 (±0.79) nM. Several interfering molecules, such as albumin, glucose, ascorbic acid, citric acid, glycine, uric acid, Na+, K+, and Cl−, were tested using the biosensor, in which no cross-reactivity was observed. The utility of the developed system to quantify creatinine in spiked serum samples was validated and the obtained percentage recoveries were found within the range of 89.71–97.30%. The fabricated biosensor was found to be highly reproducible and stable, and it retains its original signal for up to 28 days. Full article
(This article belongs to the Special Issue Trend in Optical Sensors for Medical Diagnostics and Therapeutics)
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13 pages, 2606 KiB  
Article
Optical System Based on Nafion Membrane for the Detection of Ammonia in Blood Serum Samples
by Elisabetta Pasqualotto, Erica Cretaio, Matteo Scaramuzza, Alessandro De Toni, Lara Franchin, Alessandro Paccagnella and Stefano Bonaldo
Biosensors 2022, 12(12), 1079; https://doi.org/10.3390/bios12121079 - 25 Nov 2022
Cited by 7 | Viewed by 2427
Abstract
The blood ammonia (NH3) level is one of the most important hepatic biomarkers for the diagnosis and monitoring of liver pathologies and infections. In this work, we developed an optimized optical biosensing method to extract and quantify the ammonia contained in [...] Read more.
The blood ammonia (NH3) level is one of the most important hepatic biomarkers for the diagnosis and monitoring of liver pathologies and infections. In this work, we developed an optimized optical biosensing method to extract and quantify the ammonia contained in complex-matrix samples emulating the blood serum. First, the approach was tested with solutions of phosphate-buffered saline (PBS) and ammonia chloride. Then, further trials were carried out with solutions of fetal bovine serum (FBS). The ammonia was extracted from the tested samples through a customized cell, and it was optically quantified by exploiting the indophenol reaction. The extraction cell included a cation-exchange membrane in Nafion, which was chemically pre-treated through cleaning procedures of sulfuric acid and hydrogen peroxide to keep a basic pH in the ammonia solution and to avoid contaminants in the membrane. From the NH3 solution, the indophenol reaction produced light-reactive indophenol dye molecules, which were used as colorimetric indicators. Through absorbance measurements of the indophenol dye solution at 670 nm wavelength, we were able to detect and quantify the ammonia level in the samples both with a spectrophotometer and a customized miniaturized read-out system, obtaining a detection limit of 0.029 µmol/mL. Full article
(This article belongs to the Special Issue Trend in Optical Sensors for Medical Diagnostics and Therapeutics)
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Review

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24 pages, 4288 KiB  
Review
Recent Progresses in Optical Biosensors for Interleukin 6 Detection
by Marjan Majdinasab, Marc Lamy de la Chapelle and Jean Louis Marty
Biosensors 2023, 13(9), 898; https://doi.org/10.3390/bios13090898 - 21 Sep 2023
Cited by 10 | Viewed by 2827
Abstract
Interleukin 6 (IL-6) is pleiotropic cytokine with pathological pro-inflammatory effects in various acute, chronic and infectious diseases. It is involved in a variety of biological processes including immune regulation, hematopoiesis, tissue repair, inflammation, oncogenesis, metabolic control, and sleep. Due to its important role [...] Read more.
Interleukin 6 (IL-6) is pleiotropic cytokine with pathological pro-inflammatory effects in various acute, chronic and infectious diseases. It is involved in a variety of biological processes including immune regulation, hematopoiesis, tissue repair, inflammation, oncogenesis, metabolic control, and sleep. Due to its important role as a biomarker of many types of diseases, its detection in small amounts and with high selectivity is of particular importance in medical and biological fields. Laboratory methods including enzyme-linked immunoassays (ELISAs) and chemiluminescent immunoassays (CLIAs) are the most common conventional methods for IL-6 detection. However, these techniques suffer from the complexity of the method, the expensiveness, and the time-consuming process of obtaining the results. In recent years, too many attempts have been conducted to provide simple, rapid, economical, and user-friendly analytical approaches to monitor IL-6. In this regard, biosensors are considered desirable tools for IL-6 detection because of their special features such as high sensitivity, rapid detection time, ease of use, and ease of miniaturization. In this review, current progresses in different types of optical biosensors as the most favorable types of biosensors for the detection of IL-6 are discussed, evaluated, and compared. Full article
(This article belongs to the Special Issue Trend in Optical Sensors for Medical Diagnostics and Therapeutics)
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47 pages, 5934 KiB  
Review
Progress in the Optical Sensing of Cardiac Biomarkers
by Cristina Polonschii, Monica Potara, Madalina Iancu, Sorin David, Roberta Maria Banciu, Alina Vasilescu and Simion Astilean
Biosensors 2023, 13(6), 632; https://doi.org/10.3390/bios13060632 - 7 Jun 2023
Cited by 11 | Viewed by 3686
Abstract
Biomarkers play key roles in the diagnosis, risk assessment, treatment and supervision of cardiovascular diseases (CVD). Optical biosensors and assays are valuable analytical tools answering the need for fast and reliable measurements of biomarker levels. This review presents a survey of recent literature [...] Read more.
Biomarkers play key roles in the diagnosis, risk assessment, treatment and supervision of cardiovascular diseases (CVD). Optical biosensors and assays are valuable analytical tools answering the need for fast and reliable measurements of biomarker levels. This review presents a survey of recent literature with a focus on the past 5 years. The data indicate continuing trends towards multiplexed, simpler, cheaper, faster and innovative sensing while newer tendencies concern minimizing the sample volume or using alternative sampling matrices such as saliva for less invasive assays. Utilizing the enzyme-mimicking activity of nanomaterials gained ground in comparison to their more traditional roles as signaling probes, immobilization supports for biomolecules and for signal amplification. The growing use of aptamers as replacements for antibodies prompted emerging applications of DNA amplification and editing techniques. Optical biosensors and assays were tested with larger sets of clinical samples and compared with the current standard methods. The ambitious goals on the horizon for CVD testing include the discovery and determination of relevant biomarkers with the help of artificial intelligence, more stable specific recognition elements for biomarkers and fast, cheap readers and disposable tests to facilitate rapid testing at home. As the field is progressing at an impressive pace, the opportunities for biosensors in the optical sensing of CVD biomarkers remain significant. Full article
(This article belongs to the Special Issue Trend in Optical Sensors for Medical Diagnostics and Therapeutics)
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