Underlying Mechanisms of Brain Cancer Spreading
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuro-oncology".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 1888
Special Issue Editors
Interests: brain cancer
Interests: brain tumors
Special Issue Information
Dear Colleagues,
Dissemination of tumor cells from the primary tumor causes healthy tissue infiltration and metastatic disease, and it hampers the efficacy of current cancer treatments. It is triggered by the transient or permanent induction of motility and invasiveness in the tumor cells. An essential prerequisite for primary brain tumor cell migration and invasion is the remodeling of the actin and tubulin cytoskeletons, which not only provide force, traction and rigidity but also scaffold signaling complexes in a spatially controlled manner. Hence, blocking motility and invasiveness by targeting pro-migratory cytoskeleton dynamics in tumor cells could prevent local tumor cell invasion, further dissemination from proximal metastases and the evolution towards a more aggressive phenotype.
In this special issue we soliciting manuscripts that focus on the molecular, genetic and cellular mechanisms of brain cancer spreading.
Dr. Alireza Khoshnevisan
Guest Editor
Dr. Milad Shafizadeh
Dr. Samuel Kankam
Guest Editor Assistants
Manuscript Submission Information
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Keywords
- brain tumors
- spreading
- cancer
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