Pathogenesis, Diagnosis and Treatments for Schizophrenia

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Psychiatric Diseases".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 917

Special Issue Editor


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Guest Editor
School of Medicine, University of Pittsburgh, Pittsburgh, PA 15235, USA
Interests: EEG; MEG; tDCS; TMS; neuromodulation; schizophrenia; psychosis; auditory neurophysiology; cognition

Special Issue Information

Dear Colleagues,

Schizophrenia is a common multigenic and debilitating neurological disorder characterized by chronic psychotic symptoms and psychosocial impairment. Complex interactions of genetics and environmental factors have been implicated in the etiology of schizophrenia. 

Although the current understanding of its etiology is not clear, the effect of individual psychological susceptibility and adverse factors in the external social environment on the occurrence and development of the disease has been recognized by everyone. Both susceptibility and external adverse factors may lead to the occurrence of the disease through the joint action of internal biological factors. Different factors of importance may affect different patients.

Schizophrenia usually needs to be differentiated from mental disorders caused by organic diseases and mood disorders, paranoid mental disorders, obsessive–compulsive neurosis and other diseases caused by drugs or psychoactive substances. The treatment methods for schizophrenia (schizophrenia) are mainly divided into drug treatment and psychological treatment.

This Special Issue aims to include the latest research results on schizophrenia, including but not limited to:

  1. The pathogenesis of schizophrenia;
  2. Diagnosis and treatment of first-episode schizophrenia;
  3. Complications of schizophrenia;
  4. Drug research for schizophrenia;
  5. Neuroimaging of schizophrenia;
  6. The genetics of schizophrenia;
  7. Individualized treatment approach.

Original papers (clinical and basic research) and review articles are welcome. Opinion papers will also be considered in special cases.

Dr. Brian A Coffman
Guest Editor

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Keywords

  • schizophrenia
  • neuroimaging
  • first-episode psychosis
  • genetics
  • pathogenesis
  • complications
  • antipsychotics
  • functional recovery
  • individualized treatment approach
  • cognitive impairment

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Published Papers (1 paper)

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28 pages, 2959 KiB  
Systematic Review
Dopaminergic Epistases in Schizophrenia
by Adela Bosun, Raluka Albu-Kalinovic, Oana Neda-Stepan, Ileana Bosun, Simona Sorina Farcas, Virgil-Radu Enatescu and Nicoleta Ioana Andreescu
Brain Sci. 2024, 14(11), 1089; https://doi.org/10.3390/brainsci14111089 - 29 Oct 2024
Viewed by 641
Abstract
Background: The dopaminergic theory, the oldest and most comprehensively analyzed neurotransmitter theory of schizophrenia, remains a focal point of research. Methods: This systematic review examines the association between combinations of 14 dopaminergic genes and the risk of schizophrenia. The selected genes include dopamine [...] Read more.
Background: The dopaminergic theory, the oldest and most comprehensively analyzed neurotransmitter theory of schizophrenia, remains a focal point of research. Methods: This systematic review examines the association between combinations of 14 dopaminergic genes and the risk of schizophrenia. The selected genes include dopamine receptors (DRD1–5), metabolizing enzymes (COMT, MAOA, MAOB, DBH), synthesizing enzymes (TH, DDC), and dopamine transporters (DAT, VMAT1, and VMAT2). Results: Recurring functional patterns show combinations with either hyperdopaminergic effects in limbic and striatal regions or high striatal and low prefrontal dopamine levels. The protective statuses of certain alleles or genotypes are often maintained in epistatic effects; however, exceptions exist. This complexity could explain the inconsistent results in previous genetic studies. Investigating individual alleles may be insufficient due to the heterozygous advantage observed in some studies. Conclusions: Schizophrenia may not be a monolithic disease, but rather a sum of different phenotypes which respond uniquely to different treatment and prevention approaches. Full article
(This article belongs to the Special Issue Pathogenesis, Diagnosis and Treatments for Schizophrenia)
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