Precision Medicine and Neurodegenerative Disorders: Past Lessons and New Advances
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".
Deadline for manuscript submissions: closed (15 January 2024) | Viewed by 5452
Special Issue Editor
Interests: Parkinson’s disease; Alzheimer’s dementia
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative disorders including AD and PD are complex illness that include genetic, interactome, and environmental factors. Fresh molecular and high-throughput methods are shedding new insight on the pathways and networks at the heart of this complicated diseases. This is required to go forward with the precision medicine paradigm toward novel molecular markers, systematic risk categorization, and translational targeted medicines. The implementation of a complete precision medicine strategy, as well as the creation of relevant biomarkers, are likely to result in significant advancements in recognizing, treating, and preventing neurodegenerative disorders. As a result, after more than a decade of fruitless therapy trials and one of the lowest drug discovery success rates in medicine, the time has come to thoroughly investigate the possibility of employing omics in the treatment of neurodegenerative disorders.
The present collection spans from basic research to clinical/ neuropathological studies, with an aim to instigate novel approaches towards the understanding, diagnosing and treatment of NDG disorders. We encourage submission of original empirical research articles. Furthermore, the call is open for theoretical approaches such as Reviews, Perspective, and Opinion articles on promising future directions. This Research Topic is widely open to contributions that target the following topics:
1-Hallmarks of CNS aging (genetic factors, epigenetic signatures, telomeres,…).
2-Detection of specific cell type marker genes for aging.
3-Finding the altered genes with NDG disorders.
4-Quantifying changes of different cell types in NDG disorders
5-Finding possible changes in molecular pathways in NDG disorders (e.g., signalling pathways, inflammation, alternative splicing).
6-Exploring novel cell markers that have altered expression in brain aging and NDG disorders.
7-In-depth analysis of the changes in alternative splicing in aging brain such as a comparison with additional external expression datasets (e.g., RNA-seq, from the Gene Expression Omnibus).
8-Review and perspective articles that discuss recent advances, potential contexts of use and future perspectives of genetic biomarkers in NDG disorders.
9-Animal models for studying NDG disorders.
10-Translational neuroscience research that addresses various unsolved issues in NDG disorders.
11-Researches that focus on new neuroscience disciplines like stem cell, neurotechnology (imaging, tractography, telemedicine…), personalized medicine,…etc.
Dr. Wael Mohamed Yousef Mohamed
Guest Editor
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Keywords
- neurodegenerative disorders
- dementia
- precision medicine
- biomarkers
- aging
- PD
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