Role of Inflammation, Oxidative Stress, and Metabolic Dysfunction in Neurodevelopmental and Neurodegenerative Diseases: Pharmacological Targets and Therapeutic Interventions
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".
Deadline for manuscript submissions: 16 November 2024 | Viewed by 1375
Special Issue Editor
Special Issue Information
Dear Colleagues,
Neurodegeneration is a multifactorial progressive phenomenon that primarily arises from neuronal loss in specific brain regions, which leads to various pathological manifestations including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis. Additionally, neurodevelopmental disorders such as autism, cerebral palsy, ADHD mainly occur in infants and children either due to brain damage or altered gene levels. Many of the genes and molecular pathways to be targeted require further exploration.
The etiological factors associated with neurodegenerative and neurodevelopmental disorders also include neuroinflammation, oxidative stress, mitochondrial dysfunction, brain insulin resistance and impairments of the energy metabolism. These cascades might further comprise several molecular bases that result in neurodegeneration or skewed neurodevelopment. Moreover, there are inconclusive findings regarding the pathogenesis of these diseases. Currently, it is only the symptoms of these diseases that are treated, without completely halting the progression of the disease.
This Special Issue will be focused on novel targets that influence the interconnected pathways of inflammation, oxidative stress, and metabolism directly or indirectly. Various potential pharmacological approaches and their mechanistic insights will be explored in order to reverse these detrimental features. Hence, we are soliciting papers that present cutting-edge research and review articles addressing molecular and cellular mechanisms that have not been explored in great detail previously. It is hoped that these can enhance our understanding of innovative therapeutic strategies and open avenues for future clinical research.
Dr. Ansab Akhtar
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neuroinflammation
- oxidative stress
- mitochondrial dysfunction
- metabolism
- metabolomics
- neurodegenerative diseases
- neurodevelopmental diseases
- pharmacological targets
- potential drugs
