Advances in Neuroinflammation and Neurodegeneration
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".
Deadline for manuscript submissions: closed (5 November 2021) | Viewed by 4891
Special Issue Editor
Interests: neuroinflammation; neurodegeneration; induced pluripotent stem cells; human brain cells; gene regulation
Special Issue Information
Dear Colleagues,
The immune system of the brain and the spinal cord has a protective function against exogenous infectious agents, as well as endogenous materials, including cell debris, misfolded protein, toxic metabolites, apoptotic cells, and superfluous synapses. These functions are largely mediated by the resident immune cells of the brain parenchyma—the microglia. Microglia (and other less prevalent brain immune cells) use surface receptors to survey the brain microenvironment, and transform into an activated state upon encountering danger signals, during which inflammatory molecules are released, and phagocytosis and proliferation is increased.
Under pathological conditions of neuroinflammation, immune signalling cascades may lead to spontaneous or exaggerated activation, or lead to persistent activation that never resolves. Virtually all neurodegenerative diseases involve abnormal or chronic neuroinflammation, including Alzheimer’s, Parkinson’s, Huntington’s, and Wilson’s Disease, as well as frontotemporal dementia and multiple sclerosis. Scientific explanations for the underlying processes that determine these pathological varieties of neuroinflammation remain incomplete.
In this Special Issue, we aim to focus on the latest research on neuroinflammation and neurodegeneration. We aim to present novel methods, findings, and theories with the goal of contributing to future mitigation strategies against pathological neuroinflammation with novel pharmacological interventions or life-style changes.
Dr. William Ralvenius
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neuroinflammation
- neurodegeneration
- microglia
- invading peripheral immune cells
- gliosis
