Novel Diagnosis and Treatment for Vascular Dementia

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".

Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 3455

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Guest Editor
Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy
Interests: stroke; cognitive impairment; dementia; carotid ultrasound; migraine
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Dear Colleagues,

Dementia is a worldwide epidemic. Its increasing incidence is not counterbalanced by effective therapeutic approaches, with a poor functional outcome for the affected patient and increased social costs. The importance of understanding the mechanisms of this pathology is motivated by the necessity of novel potential targets able to reduce the burden of dementia in the population. Several studies have underlined that vascular derangement is narrowly involved in dementia onset and progression both in vascular and in neurodegenerative forms, such as in Alzheimer’s disease. The role of sex, risk factors such as hypertension or diabetes, vascular pathologies such as carotid and intracranial vessel disease, and cardiac issues such as atrial fibrillation or heart failure is currently under investigation. Moreover, novel diagnostic approaches by neuroimaging, doppler ultrasound, and laboratory exams are required to allow early diagnosis and the correct follow-up of this spectrum of diseases.

The aim of this Special Issue of Brain Science is to enlighten newer pathological aspects, novel diagnostic markers, and possible evidence-based therapeutic approaches to vascular dementia.

Manuscript submissions focusing on pathogenetic, diagnostic, and therapeutic aspects of vascular dementia are welcome and encouraged.

Dr. Giovanna Viticchi
Guest Editor

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Keywords

  • Vascular dementia
  • Cognitive impairment
  • Vascular risk factors
  • Carotid ultrasound
  • Neuropsychology
  • Neuroimaging
  • Heart disease
  • Therapy

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Published Papers (1 paper)

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10 pages, 429 KiB  
Article
Atrial Fibrillation on Patients with Vascular Dementia: A Fundamental Target for Correct Management
by Giovanna Viticchi, Lorenzo Falsetti, Marco Burattini, Vincenzo Zaccone, Laura Buratti, Marco Bartolini, Gianluca Moroncini and Mauro Silvestrini
Brain Sci. 2020, 10(7), 420; https://doi.org/10.3390/brainsci10070420 - 2 Jul 2020
Cited by 5 | Viewed by 2934
Abstract
Background: Atrial fibrillation (AF) is a risk factor for cerebrovascular diseases and vascular dementia (VAD). The aim of this study was to evaluate the effect of the adherence to anticoagulant therapy guidelines in patients with dementia and AF on the risk of stroke/TIA [...] Read more.
Background: Atrial fibrillation (AF) is a risk factor for cerebrovascular diseases and vascular dementia (VAD). The aim of this study was to evaluate the effect of the adherence to anticoagulant therapy guidelines in patients with dementia and AF on the risk of stroke/TIA or major bleeding (MB). Methods: In a cohort of 1705 hospitalized patients with pre-existent AF, we observed 193 patients with vascular dementia (VAD). Non-demented AF patients were included as controls. For each subject, we calculated CHA2DS2-VASc, CHADS2, and HAS-BLED scores, and collected information regarding anticoagulant therapy, in-hospital therapeutic failure (TF) occurrence, stroke/TIA, and MB. Results: According to CHA2DS2-VASc and CHADS2 scores, 99.5% of VAD patients had the indication to anticoagulant treatment, but only 69.9% were correctly treated. During hospitalization, MB occurred in 4.66% of VAD and 8.9% of non-demented patients (p = 0.048). In-hospital stroke/TIA were observed in 24.3% of VAD and 0.8% of non-demented patients (p = 0.0001). A similar proportion of TF among patients with VAD and with normal cognition (12.9% vs. 11.2%) was observed. Conclusion: In our cohort, we observed that VAD patients with pre-existent AF were undertreated despite a higher risk of stroke/TIA with respect to non-demented patients. Full article
(This article belongs to the Special Issue Novel Diagnosis and Treatment for Vascular Dementia)
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