Electromyography in Neuromuscular Disorders

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurotechnology and Neuroimaging".

Deadline for manuscript submissions: closed (15 June 2020) | Viewed by 4069

Special Issue Editor


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Guest Editor
Department of Neurology, Martin Luther University Halle-Wittenberg, D-06120 Halle (Saale), Germany
Interests: Neuromuscular disorders; electromyography; F-wave studies; reflex investigations; late evoked potentials; Habituation

Special Issue Information

Dear Colleagues,

The International Journal of Molecular Sciences (IJMS) plans to edit a Special Volume on “Electromyography in Neuromuscular Disorders”. The issue is intended to cover a broad spectrum of important original work on all aspects of EMG research in neuromuscular disorders. Pathological spontaneous activity, and motor unit potential or recruitment analyses may also be dealt with. Conventional needle EMG studies and also investigations on special EMG techniques such as single fiber EMG or surface EMG are welcome. The Special Issue is intended to allow enough room for a thorough introduction and discussion so that, on one hand, less well-trained colleagues will benefit. On the other hand, well-trained neurophysiologists should get an overview on actual developments in the field. With these two taken together, we expect a milestone of high-ranking contemporary EMG research in neuromuscular disorders. Do not hesitate to contribute your best new data to this inaugural issue.

Prof. Dr. Malte Erich Kornhuber
Guest Editor

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Keywords

  • neuromuscular disorders
  • myopathy
  • polyneuropathy
  • needle electromyography
  • single fibre electromyography
  • surface electromyography
  • pathological spontaneous activity
  • motor unit potential analysis

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Published Papers (1 paper)

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Research

9 pages, 1042 KiB  
Article
Complex Repetitive Discharges: A Sign of Motor Axonal Reinnervation?
by Andreas Posa, Izabela Niśkiewicz, Alexander Emmer, Frank Hanisch and Malte E. Kornhuber
Brain Sci. 2020, 10(6), 349; https://doi.org/10.3390/brainsci10060349 - 5 Jun 2020
Cited by 6 | Viewed by 3784
Abstract
Complex repetitive discharges (CRDs) are poorly understood phenomena in needle electromyography (EMG) recordings. The data presented here suggest that CRDs may mainly be a sign of motor unit reinnervation. EMG “video” data of 108 CRDs from neurogenic (ND, n = 39) and myogenic [...] Read more.
Complex repetitive discharges (CRDs) are poorly understood phenomena in needle electromyography (EMG) recordings. The data presented here suggest that CRDs may mainly be a sign of motor unit reinnervation. EMG “video” data of 108 CRDs from neurogenic (ND, n = 39) and myogenic (MD, n = 14) disorders were retrospectively analyzed for cycle duration, potential-free time intervals, spike components (SC), maximum amplitudes, blockade, and increased jitter. CRD-SC in ND disorders (9.3 ± 7.8) outnumbered those in MD disorders (6.3 ± 6.2). The CRD cycle duration was correlated with SC and silent periods (p each < 0.000001). Blockade was observed in 36% and increased jitter in 27% of the CRDs. A higher number of CRD-SC in ND vs. MD fits the known differences in motor unit dimensions. Blockade and increased jitter are known features of diseased neuromuscular junctions, such as during reinnervation. The SC patterns of single CRD cycles resemble reinnervation potentials. Thus, CRDs may result from myo-axonal re-excitation in sprouting motor units. The purpose of this investigation was to better understand the circumstances under which CRDs may occur and eventually to contribute to the understanding of their pathogenesis. Full article
(This article belongs to the Special Issue Electromyography in Neuromuscular Disorders)
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