The Protective and Therapeutic Compositions in Neurological Disorders

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuropharmacology and Neuropathology".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 2133

Special Issue Editor


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Guest Editor
Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi 682 041, India.
Interests: synthesis of and pharmacological exploration of heterocyclic nucleus; CNS depressant; anticonvulsant; anticancer; antioxidant; antitubercular activity; monowave assisted synthesis; structural elucidation of organic molecules; molecular docking; dynamics; pharmacophore mapping; 3D-QSAR studies

Special Issue Information

Dear Colleagues,

The design and development of small molecules for the treatment of various neurological disorders are challenging zones in the field of medicinal chemistry. The current Issue focuses on the various class of heterocyclic scaffolds, structure–activity relationships (SARs), and in silico design of enzyme inhibitors, which are used for the management of neurodegenerative disorders, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). The Issue also focuses on plant-based inhibitors for the management of PD and AD.

Researchers are highly welcome to contribute original articles and in-depth review articles to this Special Issue that may improve our understanding of treatments for neurological disorders.

Prof. Dr. Bijo Mathew
Guest Editor

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Keywords

  • monoamine oxidase
  • acetylcholinestrase
  • Parkinson’s disease
  • Alzheimer’s disease
  • SAR
  • in silico drug design

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Published Papers (1 paper)

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Research

16 pages, 4883 KiB  
Article
Hydrogen-Rich Saline—A Novel Neuroprotective Agent in a Mouse Model of Experimental Cerebral Ischemia via the ROS-NLRP3 Inflammasome Signaling Pathway In Vivo and In Vitro
by Yuanyuan Du, Linyu Chen, Huimin Qiao, Lan Zhang, Lan Yang, Peipei Zhang, Jing Wang, Cong Zhang, Wei Jiang, Renhao Xu and Xiangjian Zhang
Brain Sci. 2023, 13(6), 939; https://doi.org/10.3390/brainsci13060939 - 10 Jun 2023
Cited by 2 | Viewed by 1525
Abstract
Background: Our previous research revealed that inflammation plays an important role in the pathophysiology of cerebral ischemia. The function of the NOD-like receptor protein 3 (NLRP3) inflammasome is to activate the inflammatory process. Recent findings suggest that reactive oxygen species (ROS) are essential [...] Read more.
Background: Our previous research revealed that inflammation plays an important role in the pathophysiology of cerebral ischemia. The function of the NOD-like receptor protein 3 (NLRP3) inflammasome is to activate the inflammatory process. Recent findings suggest that reactive oxygen species (ROS) are essential secondary messengers that activate the NLRP3 inflammasome. Hydrogen-rich saline (HS) has attracted attention for its anti-inflammatory properties. However, the protective effect and possible mechanism of HSin brain ischemia have not been well elucidated. Methods: To test the therapeutic effect of HS, we established a mouse model of distal middle cerebral artery occlusion (dMCAO) and an in vitro model of BV2 cells induced by lipopolysaccharide (LPS). The ROS scavenger N-acetylcysteine (NAC) was used to investigate the underlying mechanisms of HS. Results: HS significantly improved neurological function, reduced infarct volume, and increased cerebral blood flow in a dMCAO mouse model. ROS, NLRP3, Caspase-1, and IL-1β expression increased after cerebral ischemia, and this was reversed by HS treatment. In BV2 cells, the application of NAC further demonstrated that HS could effectively inhibit the expression of the ROS-activated NLRP3 inflammasome. Conclusions: HS, as a novel therapeutic option, could exert protect the brain by inhibiting the activation of the ROS-NLRP3 signaling pathway after cerebral ischemia. Full article
(This article belongs to the Special Issue The Protective and Therapeutic Compositions in Neurological Disorders)
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