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Brain Sciences
Special Issues
Inner Ear Therapy
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Inner Ear Therapy

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Systems Neuroscience".

Deadline for manuscript submissions: closed (10 September 2020) | Viewed by 8523

Special Issue Editor

Dr. Alexis Bozorg Grayeli

E-Mail Website
Guest Editor
Otolaryngology Department, Dijon University Hospital, Université Bourgogne-Franche Comté, F-21000 Dijon, France
Interests: otology; neurotology; surgery; hearing loss; vertigo; robotics; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Research in inner ear therapy has expanded during the past two decades focusing on targeted pharmacological actions, gene therapy, and attempts to repair the organ by stem cells. Similar to the central nervous system, the inner ear is protected by a physiological barrier which limits the access of many therapeutic agents via systemic administration. Transtympanic in-situ drug administration has been developed and refined in recent years in order to circumvent this barrier. In this Special Issue, we will gather original works and review papers on therapeutic agents in the inner ear as well as novel administration techniques.

Dr. Alexis Bozorg Grayeli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cochlea
  • vestibule
  • therapeutic agent
  • targeted administration

Published Papers (2 papers)

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Review

24 pages, 1888 KiB  
Review
Use of Super Paramagnetic Iron Oxide Nanoparticles as Drug Carriers in Brain and Ear: State of the Art and Challenges
by Caroline Guigou, Alain Lalande, Nadine Millot, Karim Belharet and Alexis Bozorg Grayeli
Brain Sci. 2021, 11(3), 358; https://doi.org/10.3390/brainsci11030358 - 11 Mar 2021
Cited by 21 | Viewed by 4330
Abstract
Drug delivery and distribution in the central nervous system (CNS) and the inner ear represent a challenge for the medical and scientific world, especially because of the blood–brain and the blood–perilymph barriers. Solutions are being studied to circumvent or to facilitate drug diffusion [...] Read more.
Drug delivery and distribution in the central nervous system (CNS) and the inner ear represent a challenge for the medical and scientific world, especially because of the blood–brain and the blood–perilymph barriers. Solutions are being studied to circumvent or to facilitate drug diffusion across these structures. Using superparamagnetic iron oxide nanoparticles (SPIONs), which can be coated to change their properties and ensure biocompatibility, represents a promising tool as a drug carrier. They can act as nanocarriers and can be driven with precision by magnetic forces. The aim of this study was to systematically review the use of SPIONs in the CNS and the inner ear. A systematic PubMed search between 1999 and 2019 yielded 97 studies. In this review, we describe the applications of the SPIONS, their design, their administration, their pharmacokinetic, their toxicity and the methods used for targeted delivery of drugs into the ear and the CNS. Full article
(This article belongs to the Special Issue Inner Ear Therapy)
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17 pages, 1582 KiB  
Review
Perspectives on Human Hearing Loss, Cochlear Regeneration, and the Potential for Hearing Restoration Therapies
by Patricia M. White
Brain Sci. 2020, 10(10), 756; https://doi.org/10.3390/brainsci10100756 - 20 Oct 2020
Cited by 9 | Viewed by 3837
Abstract
Most adults who acquire hearing loss find it to be a disability that is poorly corrected by current prosthetics. This gap drives current research in cochlear mechanosensory hair cell regeneration and in hearing restoration. Birds and fish can spontaneously regenerate lost hair cells [...] Read more.
Most adults who acquire hearing loss find it to be a disability that is poorly corrected by current prosthetics. This gap drives current research in cochlear mechanosensory hair cell regeneration and in hearing restoration. Birds and fish can spontaneously regenerate lost hair cells through a process that has become better defined in the last few years. Findings from these studies have informed new research on hair cell regeneration in the mammalian cochlea. Hair cell regeneration is one part of the greater problem of hearing restoration, as hearing loss can stem from a myriad of causes. This review discusses these issues and recent findings, and places them in the greater social context of need and community. Full article
(This article belongs to the Special Issue Inner Ear Therapy)
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