Multimodal Imaging Approach in CNS Pathologies

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurotechnology and Neuroimaging".

Deadline for manuscript submissions: closed (20 December 2020) | Viewed by 3915

Special Issue Editor


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Guest Editor
IRCCS SDN, 80143 Naples, Italy; Coma Science Group, GIGA-Research, University and University Hospital of Liege, Liege, Belgium.
Interests: PET/MR; EEG/fMRI; neurology; psychiatry; connectome; disorders of consciousness; dementia

Special Issue Information

Dear Colleagues,

Behavioral assessments could not suffice in providing accurate and complete diagnostic information in individuals with neurological and psychiatric brain disorders. Multimodal neuroimaging markers have been developed to support clinical assessments, providing simultaneously morphological, functional, molecular, and electrophysiological information which is useful to fully characterize brain pathologies. This kind of approach is important mainly in these patients where reduced compliance and unstable clinical conditions can confound clinical assessment and render differential diagnosis tricky.

Nevertheless, if hybrid scanners are only recently emerging, fewer efforts have been spent for a mutual information analysis and a real multimodal representation of these combined data.

Using different methodological techniques, from neuropsychological assessment to neuroimaging and electrophysiological recording, the aim of this Special Issue is to provide an overview of evidence illustrating the potentiality of multimodal approach to patients with neurological and psychiatric brain disorders, encompassing for dedicated multimodal phantom, hybrid acquisition, integrative analyses pipelines, multimodal networks, and connectograph visualization. We thank you for your contribution and interest.

Dr. Carlo Cavaliere
Guest Editor

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Keywords

  • PET/MR
  • EEG/fMRI
  • Multimodal imaging
  • Connectivity multidimensional analysis
  • Neuroimaging
  • Brain connectivity

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Published Papers (1 paper)

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12 pages, 1278 KiB  
Case Report
Microstructural Changes in Motor Functional Conversion Disorder: Multimodal Imaging Approach on a Case
by Mariachiara Longarzo, Carlo Cavaliere, Giulia Mele, Stefano Tozza, Liberatore Tramontano, Vincenzo Alfano, Marco Aiello, Marco Salvatore and Dario Grossi
Brain Sci. 2020, 10(6), 385; https://doi.org/10.3390/brainsci10060385 - 18 Jun 2020
Cited by 5 | Viewed by 3530
Abstract
Background: Functional motor conversion disorders are characterized by neurological symptoms unrelated to brain structural lesions. The present study was conducted on a woman presenting motor symptoms causing motor dysfunction, using advanced multimodal neuroimaging techniques, electrophysiological and neuropsychological assessment. Methods. The patient underwent fluorodeoxyglucose-positron [...] Read more.
Background: Functional motor conversion disorders are characterized by neurological symptoms unrelated to brain structural lesions. The present study was conducted on a woman presenting motor symptoms causing motor dysfunction, using advanced multimodal neuroimaging techniques, electrophysiological and neuropsychological assessment. Methods. The patient underwent fluorodeoxyglucose-positron emission tomography-computed tomography (FDG-PET-CT) and functional magnetic resonance imaging (fMRI) with both task and resting-state paradigms and was compared with 11 healthy matched controls. To test differences in structural parameters, Bayesian comparison was performed. To test differences in functional parameters, a first- and second-level analysis was performed in task fMRI, while a seed-to-seed analysis to evaluate the connections between brain regions and identify intersubject variations was performed in resting-state fMRI. Results. FDG-PET showed two patterns of brain metabolism, involving the cortical and subcortical structures. Regarding the diffusion data, microstructural parameters were altered for U-shape fibers for the hand and feet regions. Resting-state analysis showed hypoconnectivity between the parahippocampal and superior temporal gyrus. Neurophysiological assessment showed no alterations. Finally, an initial cognitive impairment was observed, paralleled by an anxiety and mild depressive state. Conclusions. While we confirmed no structural alterations sustaining this functional motor disorder, we report microstructural changes in sensory–motor integration for both the hand and feet regions that could functionally support clinical manifestations. Full article
(This article belongs to the Special Issue Multimodal Imaging Approach in CNS Pathologies)
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