Neurobiology Research of Depression
A special issue of Brain Sciences (ISSN 2076-3425).
Deadline for manuscript submissions: closed (31 December 2018) | Viewed by 4201
Special Issue Editor
Special Issue Information
Dear Colleagues,
After years of frustration and slow progress in genome-wide association studies (GWAS) in MDD; recently, different genetic approaches have significantly associated several genes to MDD and depressive symptoms in GWAS. In genetic research we have accepted the notion of depressive symptoms continuum. Does the neurobiology of this disorder also support this assumption, in which sub-threshold symptoms may have similar pathophysiological consequences? While much discussion in MDD genetic research has revolved around the heterogeneity of this disorder and the impact of ethnicity in studies, very little of those issues have reflected into its neurobiological basis research. Genetic data has also brought into light the shared genetic risk of MDD and other psychiatric disorders. Genetic consortiums have been very fruitful in several disease, as such with the increase of sample size and meta-analyses, more risk genes will be identified; thus, we should expect to have a larger inventory of MDD risk genes to account into a revamped MDD hypothesis. This special issue aims to review the wealth of recent research findings and to guide the field into a way forward in major depressive disorder (MDD) research by discussing and integrating the recent bonanza of genetic findings into our current understanding of its neurobiology.
Prof. Ma-Li WongGuest Editor
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Keywords
- MDD
- GWAS
- Ethiopathological hypothesis
- Antidepressant therapy
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