Function and Dysfunction of Peripheral Nociceptors
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".
Deadline for manuscript submissions: closed (31 July 2020) | Viewed by 8429
Special Issue Editor
Special Issue Information
Dear Colleagues,
Peripheral nociceptors with pseudounipolar cell bodies in dorsal root (DRG) and trigeminal (TG) ganglia are sensors that project to all parts of our body and warn us of actual or potential harm. With up to one-meter-long axonal processes that include components of the protein translational machinery, the ability for axon regeneration and even generation of new sensory nerve cells, combined with a special ability to interact with the immune system in absence of a blood–brain barrier, DRG and their nociceptive neurons are indeed unique. Investigations of peripheral nociceptors are hampered by their heterogeneity; there is not one source of harm, there is not one form of pain, and there is not one type of nociceptor. Consequently, differences such as expression of receptor molecules and connections to the central nervous system define subpopulations of nociceptive DRG neurons.
Furthermore, it is still not clear what signals and cues inside and outside of our body activate and sensitize peripheral nociceptors and how we can use the unique potential of these nerve cells to advance in fields such as nerve regeneration and pain measurement. Hence, it is important to provide an overview and update for researchers and clinicians.
Prof. Rainer Haberberger
Guest Editor
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Keywords
- peripheral pain
- nociception
- dorsal root ganglion
- signaling
- biomarker
- regeneration
