The Effects of Neurotransmitters on Stem Cell Differentiation

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".

Deadline for manuscript submissions: closed (26 February 2023) | Viewed by 2740

Special Issue Editors


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Guest Editor
Department of Medical Laboratories, College of Applied Medical Sciences, Majmaah University, Majmaah 15341, Saudi Arabia
Interests: neurodegenerative disorders; signaling molecules involved in the neurodegeneration; molecular and cellular neuroscience; phytochemicals and neuronal health; impact of toxicant on neuronal health

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Guest Editor
Department of Biology, College of Science, University of Hail, Hail City, Saudi Arabia
Interests: immunology; neurology; oncology; parasitology; stem cells; neuro-disorder

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Guest Editor
Zoology Department, Munger University, Munger, India
Interests: gene expression; cell culture; SDS-PAGE; immunofluorescence; western blot analysis; PCR; immunohistochemistry; flow cytometry

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Guest Editor
Department of Pharmacology and Toxicology, Jazan University, Jazan 45142, Saudi Arabia
Interests: neurosciences; neurodegenerative diseases; phytomedicine; aging disorder

Special Issue Information

Dear Colleagues,

Neurotransmitters are the various chemical compounds that facilitate communication between neurons. Neurotransmitter receptors and other proteins involved in neurotransmitter synthesis and inactivation are crucial targets for the development of therapeutic drugs intended to treat psychiatric and neurologic disorders, pain, and a variety of other disorders, because neurotransmitters play such a crucial role in brain function. Furthermore, these neurotransmitters can play specific role in stem cell differentiation. Before establishing their correlation, there are some points to be explored. For example, do all neurotransmitters support neurogenesis or have some antagonistic effects along with growth factors? There is growing evidence that changes in neurotransmitter signaling have an impact on adult neurogenesis. Because of the variety and context-dependency of these effects, more research is necessary to fully understand how different neurotransmitter signaling pathways regulate neurogenesis. It appears crucial that we improve and supplement the dominant approach of systemic drug administration if we are to deepen our understanding of how neurotransmitters mediate information flow between neurons and their progenitors.

We are seeking entries for this Special Issue that answer some of the abovementioned questions. We wish to establish a multidisciplinary basis of evidence by combining recent findings from several disciplines, such as neurobiology, neuropsychology, and stem cells.

Hence, from observational, experimental, and clinical investigations, we are seeking research papers, reviews, and commentaries on a variety of neurotransmitters, growth factors, and aspects of stem cell differentiation.

Dr. Sadaf Jahan
Dr. Arif Jamal Siddiqui
Dr. Dipak Kumar
Dr. Andleeb Khan
Guest Editors

Manuscript Submission Information

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Keywords

  • neurotransmitters
  • neurobiology
  • neuropsychology
  • neurogenesis
  • stem cells
  • psychiatric disorder
  • neurologic disorder

Published Papers (1 paper)

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Research

14 pages, 3417 KiB  
Article
Whole-Exome Sequencing Reveals Migraine-Associated Novel Functional Variants in Arab Ancestry Females: A Pilot Study
by Johra Khan, Lubna Al Asoom, Ahmad Al Sunni, Nazish Rafique, Rabia Latif, Majed Alabdali, Azhar Alhariri, Majed Aloqaily, Sayed AbdulAzeez, Sadaf Jahan, Saeed Banawas and J. Francis Borgio
Brain Sci. 2022, 12(11), 1429; https://doi.org/10.3390/brainsci12111429 - 24 Oct 2022
Cited by 1 | Viewed by 2047
Abstract
Migraine, as the seventh most disabling neurological disease with 26.9% prevalence in Saudi females, lacks studies on identifying associated genes and pathways with migraines in the Arab population. This case control study aims to identify the migraine-associated novel genes and risk variants. More [...] Read more.
Migraine, as the seventh most disabling neurological disease with 26.9% prevalence in Saudi females, lacks studies on identifying associated genes and pathways with migraines in the Arab population. This case control study aims to identify the migraine-associated novel genes and risk variants. More than 1900 Arab ancestry young female college students were screened: 103 fulfilled the ICHD-3 criteria for migraine and 20 cases confirmed in the neurology clinic were included for the study with age-matched healthy controls. DNA from blood samples were subjected to paired-end whole-exome sequencing. After quality control, 3365343 missense, frameshift, missense splice region variants and insertion–deletion (indels) polymorphisms were tested for association with migraine. Significant variants were validated using Sanger sequencing. A total of 17 (p-value 9.091 × 10−05) functional variants in 12 genes (RETNLB, SCAI, ADH4, ESPL1, CPT2, FLG, PPP4R1, SERPINB5, ZNF66, ETAA1, EXO1 and CPA6) were associated with higher migraine risk, including a stop-gained frameshift (-13-14*SX) variant in the gene RETNLB (rs5851607; p-value 3.446 × 10−06). Gene analysis revealed that half of the significant novel migraine risk genes were expressed in the temporal lobe (p-value 0.0058) of the cerebral cortex. This is the first study exploring the migraine risk of 17 functional variants in 12 genes among Saudi female migraineurs of Arab ancestry using whole-exome sequencing. Half of the significant genes were expressed in the temporal lobe, which expands migraine pathophysiology and early identification using biomarkers for research possibilities on personalised genetics. Full article
(This article belongs to the Special Issue The Effects of Neurotransmitters on Stem Cell Differentiation)
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