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Brain Sciences
Special Issues
Advance in Neurodegenerative Diseases: Glial Perspective
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Advance in Neurodegenerative Diseases: Glial Perspective

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 3093

Special Issue Editor

Dr. Junhui Wang

E-Mail Website
Guest Editor
Mount Sinai Hospital, 600 University Avenue, Toronto, ON, Canada
Interests: the interactions between neurons and astrocytes; the role of astrocytes in neurodegenerative diseases (especially tauotopathy, lewy body and AD)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the recent decade, the roles of glial cells in the pathogenesis and progression of neurodegenerative diseases have been attracting a plethora of attention. Accumulating evidences from clinical pathology and preclinical studies proved that glial cells are the sine qua non elements of these diseases and even becoming the key players for distinguishing diagnosis of different forms of neurodegenerative diseases, such as corticobasal degeneration (CBD) and frontotemporal degeneration (FTD).

This Special Issue of Brain Sciences aims to present a collection of studies delineating the most recent advancements in the field of neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, tauopathies, α-synucleinopathies and other proteinopathies in CNS, etc.) by exploring the unique role of glial cells, including astrocytes, microglia, oligodendrocytes etc. Research articles covering the recent progress, from clinical to pre-clinical studies with variety of experimental setups, both in vitro and in vivo are welcome. We also encourage the submission of reviews or mini-review relevant to this topic, in particular summarizing the recent progress in systemic and comprehensive ways. Case reports presenting some rare glia-related conditions from clinical setting with the imaging or neuropathology pattern are also welcome.

Dr. Junhui Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurodegenerative diseases
  • glia
  • clinical
  • pre-clinical
  • neuropathology

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Published Papers (1 paper)

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Research

21 pages, 6686 KiB  
Article
Lipopolysaccharide Preconditioning Restricts Microglial Overactivation and Alleviates Inflammation-Induced Depressive-like Behavior in Mice
by Haiping Yu, Junli Kan, Mingming Tang, Yanbing Zhu and Baoyang Hu
Brain Sci. 2023, 13(4), 549; https://doi.org/10.3390/brainsci13040549 - 25 Mar 2023
Cited by 5 | Viewed by 2632
Abstract
Overactive microglia and severe neuroinflammation play crucial roles in the development of major depressive disorder. Preconditioning with lipopolysaccharide (LPS) provides protection against severe neuroinflammation. However, administering high doses of LPS to mice triggers depressive symptoms. Therefore, the optimal dose of LPS preconditioning needs [...] Read more.
Overactive microglia and severe neuroinflammation play crucial roles in the development of major depressive disorder. Preconditioning with lipopolysaccharide (LPS) provides protection against severe neuroinflammation. However, administering high doses of LPS to mice triggers depressive symptoms. Therefore, the optimal dose of LPS preconditioning needs to be determined by further experiments. LPS preconditioning is an effective agent in anti-inflammation and neuroprotection, but the mechanism by which LPS preconditioning acts in depression remain unclear. This study finds that the anti-inflammation mechanism of low-dose LPS preconditioning is mainly dependent on G-protein-coupled receptor 84 (GPR84). We use low-dose LPS for preconditioning and re-challenged mice or BV2 microglia with high-dose LPS. In addition, RNA-seq is used to explore underlying changes with LPS preconditioning. Low-dose LPS preconditioning reduces the expression of pro-inflammatory mediators and inhibits microglial activation, as well as suppresses the depressive-like behavior when the mice are re-challenged with high-dose LPS. Further investigation reveals that the tolerance-like response in microglia is dependent on the GPR84. Here, we show that low-dose LPS preconditioning can exert anti-inflammation effects and alleviates inflammation-induced depressive-like behavior in mice. As a potential therapeutic target for depression, LPS preconditioning needs to be given further attention regarding its effectiveness and safety. Full article
(This article belongs to the Special Issue Advance in Neurodegenerative Diseases: Glial Perspective)
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