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Cancers
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Surgery for Cervical Cancer
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Surgery for Cervical Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (31 May 2025) | Viewed by 1746

Special Issue Editor

Dr. Jiantai Timothy Qiu

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei 110301, Taiwan
Interests: cancer immunotherapy; minimally invasive gynecologic surgery

Special Issue Information

Dear Colleagues,

Welcome to our Special Issue on “Surgery for Cervical Cancer”. This Special Issue delves into the multifaceted aspects of surgical interventions aimed at combating cervical cancer. From innovative surgical techniques to adjuvant therapies, we explore the latest advancements in this field. Cervical cancer remains a significant global health challenge, and this Special Issue aims to shed light on the current state of surgical interventions, their efficacy, and their impact on patient outcomes. We welcome contributions that discuss surgical approaches, outcomes, complications, and future directions in the management of cervical cancer. Together, let us deepen our understanding and explore new frontiers in the fight against this disease.

Kind regards,

Dr. Jiantai Timothy Qiu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cervical cancer
  • surgical approaches
  • surgical interventions
  • adjutant therapies

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Published Papers (1 paper)

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Review

16 pages, 603 KB  
Review
Current Updates on Surgical Management of Patients with Early-Stage Cervical Cancer
by María Clara Santía, Tommaso Meschini, Heng-Cheng Hsu, Paula Mateo-Kubach, Elise M. Yates, Karolina Kilowski, Behrouz Zand, Rene Pareja and Pedro T. Ramirez
Cancers 2025, 17(13), 2259; https://doi.org/10.3390/cancers17132259 - 7 Jul 2025
Cited by 2 | Viewed by 1294
Abstract
The recommended treatment for early-stage cervical cancer (FIGO 2018 stages IA–IB2 and selected IIA1) is surgery, followed by either observation or adjuvant therapy, based on individual risk factors. Surgical management has evolved from extensive radical procedures to more conservative strategies, allowing for fertility-preserving [...] Read more.
The recommended treatment for early-stage cervical cancer (FIGO 2018 stages IA–IB2 and selected IIA1) is surgery, followed by either observation or adjuvant therapy, based on individual risk factors. Surgical management has evolved from extensive radical procedures to more conservative strategies, allowing for fertility-preserving options in appropriately selected patients. In 2018, a landmark study (LACC trial) evaluated the surgical approach to radical hysterectomy, comparing open vs. minimally invasive surgery. The results demonstrated that minimally invasive surgery was associated with worse disease-free and overall survival, leading to guidelines changes that recommend the open radical hysterectomy as the new standard of care. More recently, results from the prospective randomized SHAPE trial demonstrated that in well-selected patients with low-risk early-stage cervical cancer, recurrence rates are comparable between simple hysterectomy and radical hysterectomy. An ongoing study, the CONTESSA trial, is evaluating the role of neoadjuvant chemotherapy in the setting of fertility preservation for lesions measuring 2–4 cm. In addition, ongoing studies are evaluating different surgical approaches for both simple hysterectomy (LASH trial) and radical hysterectomy (ROCC/GOG-3043 and RACC trials), with a focus on comparing oncologic outcomes. Attention has also turned to refining lymph node assessment. Sentinel lymph node biopsy has become a standard staging strategy with reduced morbidity. The SENTICOL I-II and SENTIX/ENGOT-Cx2 trials support its safety and diagnostic accuracy in early-stage disease. This article offers a comprehensive overview of recently published prospective trials that have shaped clinical practice in the management of early-stage cervical cancer. It focuses on surgical approaches and radicality, the role of sentinel lymph node mapping, and fertility-sparing treatments. The review further draws attention to ongoing investigations and novel studies that may influence future directions in the field. Full article
(This article belongs to the Special Issue Surgery for Cervical Cancer)
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